New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs
Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and progn...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2021-08, Vol.140, p.111753-111753, Article 111753 |
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| container_title | Biomedicine & pharmacotherapy |
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| creator | Mahjoubin-Tehran, Maryam Rezaei, Samaneh Jesmani, Amin Birang, Nafise Morshedi, Korosh Khanbabaei, Hashem Khan, Haroon Piranviseh, Ashkan Nejati, Majid Aschner, Michael Mirzaei, Hamed |
| description | Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke. |
| doi_str_mv | 10.1016/j.biopha.2021.111753 |
| format | Article |
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| issn | 0753-3322 1950-6007 |
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| source | Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Long non-coding RNAs MicroRNAs Pathogenesis Stroke |
| title | New epigenetic players in stroke pathogenesis: From non-coding RNAs to exosomal non-coding RNAs |
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