Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa
A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she...
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| Veröffentlicht in: | Internal Medicine 2021/06/01, Vol.60(11), pp.1731-1736 |
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| container_title | Internal Medicine |
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| creator | Koda, Ryo Miyazaki, Satoru Iino, Noriaki Sato, Yo Hirano, Kenichiro Sunami, Eiji Kosugi, Shinichi Kanefuji, Tsutomu Ogose, Akira Narita, Ichiei |
| description | A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia. |
| doi_str_mv | 10.2169/internalmedicine.5911-20 |
| format | Article |
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Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.5911-20</identifier><identifier>PMID: 33390486</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Anorexia ; anorexia nervosa ; Case Report ; Colon cancer ; Eating disorders ; Fractures ; Hypocalcemia ; Internal medicine ; Intestine ; Malabsorption ; Nutrient deficiency ; Osteomalacia ; Vitamin D ; vitamin D deficiency ; Vitamin deficiency</subject><ispartof>Internal Medicine, 2021/06/01, Vol.60(11), pp.1731-1736</ispartof><rights>2021 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2021</rights><rights>Copyright © 2021 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-dfc3a9f8516d66a5487d6b36024869bf56ad47633b7969a4bfaa9e65139202863</citedby><cites>FETCH-LOGICAL-c610t-dfc3a9f8516d66a5487d6b36024869bf56ad47633b7969a4bfaa9e65139202863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222131/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222131/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33390486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koda, Ryo</creatorcontrib><creatorcontrib>Miyazaki, Satoru</creatorcontrib><creatorcontrib>Iino, Noriaki</creatorcontrib><creatorcontrib>Sato, Yo</creatorcontrib><creatorcontrib>Hirano, Kenichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Kosugi, Shinichi</creatorcontrib><creatorcontrib>Kanefuji, Tsutomu</creatorcontrib><creatorcontrib>Ogose, Akira</creatorcontrib><creatorcontrib>Narita, Ichiei</creatorcontrib><title>Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 48-year-old woman with a 9-year-history of anorexia nervosa (AN) was admitted complaining of generalized bone pain. Blood tests showed hypocalcemia and hyperphosphatasemia, and a radiological survey revealed multiple rib fractures, suggesting complication with osteomalacia. Two years earlier, she had undergone subtotal colectomy for colon cancer. Her serum 25-hydroxy vitamin D concentration was below the detectable level. In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.</description><subject>Anorexia</subject><subject>anorexia nervosa</subject><subject>Case Report</subject><subject>Colon cancer</subject><subject>Eating disorders</subject><subject>Fractures</subject><subject>Hypocalcemia</subject><subject>Internal medicine</subject><subject>Intestine</subject><subject>Malabsorption</subject><subject>Nutrient deficiency</subject><subject>Osteomalacia</subject><subject>Vitamin D</subject><subject>vitamin D deficiency</subject><subject>Vitamin deficiency</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNplkU1v1DAQhi0EokvhL6BIXLik-CN27AtS1fIlrVgOwNWaOJOuV4lTbKfQf49Xu6ygXMaHefzOO_MSUjF6wZkyb3zIGAOME_be-YAX0jBWc_qIrJhoTN1yIR-TFTVM17yUM_IspR2lQreGPyVnQghDG61WZP3dZ5h8qK6raxyKGAZ3X_vQLw77apMyzhOM4DxUBYLqC-SC5Oqnz9vqMswRf5XWZ4x3c4Ln5MkAY8IXx_ecfHv_7uvVx3q9-fDp6nJdO8VorvvBCTCDlkz1SoFsdNurTijKiyXTDVJB37RKiK41ykDTDQAGlWTCcMq1Eufk7UH3dunKCVwxFGG0t9FPEO_tDN7-2wl-a2_mO6s550ywIvD6KBDnHwumbCefHI4jBJyXZHnTSmokZ7Sgrx6gu3nZ375QUkjDmW5FofSBcnFOKeJwMsOo3UdmH0Zm95FZvh_w8u9lTh__ZFSAzQHYpQw3eAIgZu9G_F9ZUVukSz2OOJFuC9FiEL8BWae0gg</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Koda, Ryo</creator><creator>Miyazaki, Satoru</creator><creator>Iino, Noriaki</creator><creator>Sato, Yo</creator><creator>Hirano, Kenichiro</creator><creator>Sunami, Eiji</creator><creator>Kosugi, Shinichi</creator><creator>Kanefuji, Tsutomu</creator><creator>Ogose, Akira</creator><creator>Narita, Ichiei</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210601</creationdate><title>Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa</title><author>Koda, Ryo ; Miyazaki, Satoru ; Iino, Noriaki ; Sato, Yo ; Hirano, Kenichiro ; Sunami, Eiji ; Kosugi, Shinichi ; Kanefuji, Tsutomu ; Ogose, Akira ; Narita, Ichiei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-dfc3a9f8516d66a5487d6b36024869bf56ad47633b7969a4bfaa9e65139202863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anorexia</topic><topic>anorexia nervosa</topic><topic>Case Report</topic><topic>Colon cancer</topic><topic>Eating disorders</topic><topic>Fractures</topic><topic>Hypocalcemia</topic><topic>Internal medicine</topic><topic>Intestine</topic><topic>Malabsorption</topic><topic>Nutrient deficiency</topic><topic>Osteomalacia</topic><topic>Vitamin D</topic><topic>vitamin D deficiency</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koda, Ryo</creatorcontrib><creatorcontrib>Miyazaki, Satoru</creatorcontrib><creatorcontrib>Iino, Noriaki</creatorcontrib><creatorcontrib>Sato, Yo</creatorcontrib><creatorcontrib>Hirano, Kenichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Kosugi, Shinichi</creatorcontrib><creatorcontrib>Kanefuji, Tsutomu</creatorcontrib><creatorcontrib>Ogose, Akira</creatorcontrib><creatorcontrib>Narita, Ichiei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koda, Ryo</au><au>Miyazaki, Satoru</au><au>Iino, Noriaki</au><au>Sato, Yo</au><au>Hirano, Kenichiro</au><au>Sunami, Eiji</au><au>Kosugi, Shinichi</au><au>Kanefuji, Tsutomu</au><au>Ogose, Akira</au><au>Narita, Ichiei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. 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In addition to a poor nutritional intake and insufficient sun exposure, malabsorption of fat-soluble substances in the intestine and phosphate loss from the kidneys might have contributed to the development of her osteomalacia.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>33390486</pmid><doi>10.2169/internalmedicine.5911-20</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; PubMed Central Open Access; PubMed Central |
| subjects | Anorexia anorexia nervosa Case Report Colon cancer Eating disorders Fractures Hypocalcemia Internal medicine Intestine Malabsorption Nutrient deficiency Osteomalacia Vitamin D vitamin D deficiency Vitamin deficiency |
| title | Vitamin D Deficiency-induced Osteomalacia in a Patient with Anorexia Nervosa |
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