Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism

Group 3 innate lymphoid cells (ILC3) have a prominent role in the maintenance of intestine mucosa homeostasis. The hypoxia-inducible factor (HIF) is an important modulator of immune cell activation and a key mechanism for cellular adaptation to oxygen deprivation. However, its role on ILC3 is not we...

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Veröffentlicht in:	Mucosal immunology 2021-07, Vol.14 (4), p.828-841
Hauptverfasser:	Fachi, J. L., Pral, L. P., dos Santos, J. A. C., Codo, A. C., de Oliveira, S., Felipe, J. S., Zambom, F. F. F., Câmara, N. O. S., Vieira, P. M. M. M., Colonna, M., Vinolo, M. A. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Animals Antibodies Biomedical and Life Sciences Biomedicine Cell activation Clostridium Infections - etiology Clostridium Infections - metabolism Disease Models, Animal Disease Susceptibility Epithelium Gastroenterology Glycolysis Homeostasis Hypoxia Hypoxia - immunology Hypoxia - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Immunity, Innate Immunology Interleukin 17 Interleukin 22 Intestine Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocyte Subsets - immunology Lymphocyte Subsets - metabolism Lymphoid cells Mice Mice, Knockout Mitochondria - metabolism Mucosa Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Oxygen Protein Stability Signal Transduction TOR protein TOR Serine-Threonine Kinases - metabolism Transcription
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