Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

Despite the introduction of public health measures and spike protein-based vaccines to mitigate the COVID-19 pandemic, SARS-CoV-2 infections and deaths continue to have a global impact. Previously, we used a structural design approach to develop picomolar range miniproteins targeting the SARS-CoV-2...

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Veröffentlicht in:	Cell host & microbe 2021-07, Vol.29 (7), p.1151-1161.e5
Hauptverfasser:	Case, James Brett, Chen, Rita E., Cao, Longxing, Ying, Baoling, Winkler, Emma S., Johnson, Max, Goreshnik, Inna, Pham, Minh N., Shrihari, Swathi, Kafai, Natasha M., Bailey, Adam L., Xie, Xuping, Shi, Pei-Yong, Ravichandran, Rashmi, Carter, Lauren, Stewart, Lance, Baker, David, Diamond, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Angiotensin-Converting Enzyme 2 Animals COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Disease Models, Animal Female Humans intranasal Lung - immunology Male Mice Mice, Inbred C57BL miniprotein Pandemics - prevention & control pathogenesis prophylaxis Protein Binding receptor-binding domain SARS-CoV-2 SARS-CoV-2 - immunology Serine C-Palmitoyltransferase Spike Glycoprotein, Coronavirus - chemistry therapy variants Viral Load
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