Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease

Reductions of baseline cerebral blood flow (CBF) of ∼10–20% are a common symptom of Alzheimer’s disease (AD) that appear early in disease progression and correlate with the severity of cognitive impairment. These CBF deficits are replicated in mouse models of AD and recent work shows that increasing...

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Veröffentlicht in:	Journal of Cerebral Blood Flow & Metabolism 2021-07, Vol.41 (7), p.1501-1516
Hauptverfasser:	Bracko, Oliver, Cruz Hernández, Jean C, Park, Laibaik, Nishimura, Nozomi, Schaffer, Chris B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - etiology Alzheimer Disease - pathology Animals Cerebrovascular Circulation Cerebrovascular Disorders - complications Disease Models, Animal Humans Review
Online-Zugang:	Volltext
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