Renal replacement therapy in cancer patients with acute kidney injury (Review)
Cancer patients are at high risk for developing acute kidney injury (AKI), which is associated with increased morbidity and mortality in these patients. Despite the progress made in understanding the pathogenic mechanisms and etiology of AKI in these patients, the main prevention consists of avoidin...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2021-08, Vol.22 (2), Article 864 |
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| container_title | Experimental and therapeutic medicine |
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| creator | Lupuşoru, Mircea Lupuşoru, Gabriela Ailincăi, Ioana Frățilă, Georgiana Andronesi, Andreea Micu, Elena Banu, Mihaela Costea, Radu Ismail, Gener |
| description | Cancer patients are at high risk for developing acute kidney injury (AKI), which is associated with increased morbidity and mortality in these patients. Despite the progress made in understanding the pathogenic mechanisms and etiology of AKI in these patients, the main prevention consists of avoiding medication and nephrotoxic agents such as non-steroidal anti-inflammatory drugs, contrast agents used in medical imaging and modulation of chemotherapy regimens; when prophylactic measures are overcome and renal impairment becomes unresponsive to treatment, renal replacement therapy (RRT) is required. There are several methods of RRT that can be utilized for patients with malignancies and acute renal impairment; the choice of treatment being based on the patient characteristics. The aim of this article is to review the literature data regarding the epidemiology and management of AKI in cancer patients, the extracorporeal techniques used, choice of the appropriate therapy and the optimal time of initiation, and also the dose-prognosis relationship. |
| doi_str_mv | 10.3892/etm.2021.10296 |
| format | Article |
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Despite the progress made in understanding the pathogenic mechanisms and etiology of AKI in these patients, the main prevention consists of avoiding medication and nephrotoxic agents such as non-steroidal anti-inflammatory drugs, contrast agents used in medical imaging and modulation of chemotherapy regimens; when prophylactic measures are overcome and renal impairment becomes unresponsive to treatment, renal replacement therapy (RRT) is required. There are several methods of RRT that can be utilized for patients with malignancies and acute renal impairment; the choice of treatment being based on the patient characteristics. 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Despite the progress made in understanding the pathogenic mechanisms and etiology of AKI in these patients, the main prevention consists of avoiding medication and nephrotoxic agents such as non-steroidal anti-inflammatory drugs, contrast agents used in medical imaging and modulation of chemotherapy regimens; when prophylactic measures are overcome and renal impairment becomes unresponsive to treatment, renal replacement therapy (RRT) is required. There are several methods of RRT that can be utilized for patients with malignancies and acute renal impairment; the choice of treatment being based on the patient characteristics. 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| subjects | Acids Acute renal failure Cancer patients Cancer therapies Care and treatment Chemotherapy Creatinine Dialyzers Edema Electrolytes Hemodialysis Hypotension Intensive care Ischemia Kidneys Medical prognosis Mortality Patients Prostate cancer Renal replacement therapy Review Risk factors Tumor necrosis factor-TNF Uterus |
| title | Renal replacement therapy in cancer patients with acute kidney injury (Review) |
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