Role of microRNAs in intervertebral disc degeneration (Review)
The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unkn...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2021-08, Vol.22 (2), p.860-860, Article 860 |
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| creator | Yang, Fengguang Wang, Jizu Chen, Zhixin Yang, Yuping Zhang, Wenhui Guo, Shifang Yang, Qingshan |
| description | The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD. |
| doi_str_mv | 10.3892/etm.2021.10292 |
| format | Article |
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IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2021.10292</identifier><identifier>PMID: 34178133</identifier><language>eng</language><publisher>Athens: Spandidos Publications</publisher><subject>Apoptosis ; Back pain ; Binding sites ; Cell cycle ; Cell growth ; Collagen ; Degenerative disc disease ; Development and progression ; Gene expression ; Genetic aspects ; Health aspects ; Inflammation ; Intervertebral disk ; MicroRNA ; MicroRNAs ; Physiology ; Review ; Spinal diseases</subject><ispartof>Experimental and therapeutic medicine, 2021-08, Vol.22 (2), p.860-860, Article 860</ispartof><rights>COPYRIGHT 2021 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2021</rights><rights>Copyright: © Yang et al. 2020</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-1076b62a8c516a3ac0ee848e00afafb023120c78380f6e23e6eff77348dc84953</citedby><cites>FETCH-LOGICAL-c392t-1076b62a8c516a3ac0ee848e00afafb023120c78380f6e23e6eff77348dc84953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220656/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220656/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids></links><search><creatorcontrib>Yang, Fengguang</creatorcontrib><creatorcontrib>Wang, Jizu</creatorcontrib><creatorcontrib>Chen, Zhixin</creatorcontrib><creatorcontrib>Yang, Yuping</creatorcontrib><creatorcontrib>Zhang, Wenhui</creatorcontrib><creatorcontrib>Guo, Shifang</creatorcontrib><creatorcontrib>Yang, Qingshan</creatorcontrib><title>Role of microRNAs in intervertebral disc degeneration (Review)</title><title>Experimental and therapeutic medicine</title><description>The incidence of lower back pain caused by intervertebral disc degeneration (IDD) is gradually increasing. IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. Further research is expected to identify markers for early diagnosis of IDD and new targets for delaying or reversing IDD.</description><subject>Apoptosis</subject><subject>Back pain</subject><subject>Binding sites</subject><subject>Cell cycle</subject><subject>Cell growth</subject><subject>Collagen</subject><subject>Degenerative disc disease</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Intervertebral disk</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Physiology</subject><subject>Review</subject><subject>Spinal diseases</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkV1rVDEQhoMotrS99fqAN_Vi13ycfN0UlmJVKBYWvQ7ZnMmack5Sk7Nb_Ped1UVRmgQSkmfezMxLyBtGl8JY_h7mackpZ0tGueUvyCnTli8YZfLl8UytYSfkorV7ikMqZox8TU5Ez7RhQpySq3UZoSuxm1KoZf1l1bqUcc1Q91Bn2FQ_dkNqoRtgCxmqn1PJ3eUa9gke352TV9GPDS6O-xn5dvPh6_Wnxe3dx8_Xq9tFEJbPmJJWG8W9CZIpL3ygAKY3QKmPPm4oF4zToI0wNCrgAhTEqLXozRBMb6U4I1e_dR92mwmGAHnGxNxDTZOvP13xyf37ktN3ty17ZzinSioUuDwK1PJjB212ExYF4-gzlF1zXPbSWiF0j-jb_9D7sqsZy0MKW2iZ6ulfautHcCnHgv-Gg6hbKc2U1FQKpJbPUDgHwIaXDDHh_XMB6EZrFeKfGhl1B9Mdmu4Oprtfposntf2bTQ</recordid><startdate>20210801</startdate><enddate>20210801</enddate><creator>Yang, Fengguang</creator><creator>Wang, Jizu</creator><creator>Chen, Zhixin</creator><creator>Yang, Yuping</creator><creator>Zhang, Wenhui</creator><creator>Guo, Shifang</creator><creator>Yang, Qingshan</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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IDD not only affects the quality of life of the patients, but also poses a major socioeconomic burden. There is currently no optimal method for delaying or reversing IDD, mainly due to its unknown pathogenesis. MicroRNAs (miRNAs/miRs) participate in the development of a number of diseases, including IDD. Abnormal expression of miRNAs in the intervertebral disc is implicated in various pathological processes underlying the development of IDD, including nucleus pulposus (NP) cell (NPC) proliferation, NPC apoptosis, extracellular matrix remodeling, inflammation and cartilaginous endplate changes, among others. The focus of the present review was the advances in research on the involvement of miRNAs in the mechanism underlying IDD. 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| subjects | Apoptosis Back pain Binding sites Cell cycle Cell growth Collagen Degenerative disc disease Development and progression Gene expression Genetic aspects Health aspects Inflammation Intervertebral disk MicroRNA MicroRNAs Physiology Review Spinal diseases |
| title | Role of microRNAs in intervertebral disc degeneration (Review) |
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