Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic
Background The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic. Methods All patients with KD admitted between February and April in 2015–2020, were classif...
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| Veröffentlicht in: | World journal of pediatrics : WJP 2021-06, Vol.17 (3), p.263-271 |
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| creator | Ding, Yue-Yue Ren, Yan Qin, Jie Qian, Guang-Hui Tang, Yun-Jia Chen, Ye Li, Xuan Xu, Lei Qiao, Chun-Hong Sun, Ling Lv, Hai-Tao |
| description | Background
The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods
All patients with KD admitted between February and April in 2015–2020, were classified into before (group 1, in 2015–2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (
n
= 98) and non-KD (
n
= 4644)] referred to
Mycoplasma pneumoniae
(MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results
Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion
Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic. |
| doi_str_mv | 10.1007/s12519-021-00431-2 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8219783</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><wanfj_id>ssekzz202103006</wanfj_id><sourcerecordid>ssekzz202103006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-10c25c7dec5a5a7ed2715eac5576c4c00e42f39ece0ecef795d64ce39f61dd573</originalsourceid><addsrcrecordid>eNp9UcFu1DAUtBAVLYUf4IB842R4duI4uSChpUBFpV6Aq_V4dnbdzdorO0vVfj0ugUIvHJ7ekzwzHs0w9kLCawlg3hSptBwEKCkA2kYK9YidyL4zArrePK63gV70uhuO2dNSrgA6JTt4wo6btm5j4IRtV1OIgXDitMGMNPscyhyo8DTyz3iNBbeBu1A8Fs8xOk4p0iFnH2e-x3mT1j4W7g45xDUPJU04hxR5iHx1-e38vZBDhUXnd4GesaMRp-Kf_96n7OuHsy-rT-Li8uP56t2FoNb0s5BASpNxnjRqNN4pI7VH0tp01BKAb9XYDJ481BnNoF3Xkm-GsZPOadOcsreL7v7wfecdVasZJ7vPYYf5xiYM9uFLDBu7Tj9sr-Rg-qYKvFoErjGOGNf2Kh1yrJZtKX57e6tq5NDUOCtSLUjKqZTsx_tfJNi7kuxSkq0M-6skqyrp5b_-7il_WqmAZgGU_V2sPv818B_Zn8ken_k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Ding, Yue-Yue ; Ren, Yan ; Qin, Jie ; Qian, Guang-Hui ; Tang, Yun-Jia ; Chen, Ye ; Li, Xuan ; Xu, Lei ; Qiao, Chun-Hong ; Sun, Ling ; Lv, Hai-Tao</creator><creatorcontrib>Ding, Yue-Yue ; Ren, Yan ; Qin, Jie ; Qian, Guang-Hui ; Tang, Yun-Jia ; Chen, Ye ; Li, Xuan ; Xu, Lei ; Qiao, Chun-Hong ; Sun, Ling ; Lv, Hai-Tao</creatorcontrib><description>Background
The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods
All patients with KD admitted between February and April in 2015–2020, were classified into before (group 1, in 2015–2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (
n
= 98) and non-KD (
n
= 4644)] referred to
Mycoplasma pneumoniae
(MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results
Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion
Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.</description><identifier>ISSN: 1708-8569</identifier><identifier>EISSN: 1867-0687</identifier><identifier>DOI: 10.1007/s12519-021-00431-2</identifier><identifier>PMID: 34160770</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adolescent ; Child ; Child, Preschool ; COVID-19 - epidemiology ; Critical Care Medicine ; Female ; Humans ; Imaging ; Incidence ; Infant ; Intensive ; Male ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Mucocutaneous Lymph Node Syndrome - epidemiology ; Original ; Original Article ; Pandemics ; Pediatric Surgery ; Pediatrics ; Physical Distancing ; Pneumonia, Mycoplasma - epidemiology ; Radiology ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - microbiology ; Retrospective Studies ; SARS-CoV-2 ; Surgery ; Virus Diseases - epidemiology ; Virus Diseases - virology</subject><ispartof>World journal of pediatrics : WJP, 2021-06, Vol.17 (3), p.263-271</ispartof><rights>Children's Hospital, Zhejiang University School of Medicine 2021</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-10c25c7dec5a5a7ed2715eac5576c4c00e42f39ece0ecef795d64ce39f61dd573</citedby><cites>FETCH-LOGICAL-c478t-10c25c7dec5a5a7ed2715eac5576c4c00e42f39ece0ecef795d64ce39f61dd573</cites><orcidid>0000-0001-5993-9248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/ssekzz/ssekzz.jpg</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12519-021-00431-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12519-021-00431-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34160770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Yue-Yue</creatorcontrib><creatorcontrib>Ren, Yan</creatorcontrib><creatorcontrib>Qin, Jie</creatorcontrib><creatorcontrib>Qian, Guang-Hui</creatorcontrib><creatorcontrib>Tang, Yun-Jia</creatorcontrib><creatorcontrib>Chen, Ye</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Qiao, Chun-Hong</creatorcontrib><creatorcontrib>Sun, Ling</creatorcontrib><creatorcontrib>Lv, Hai-Tao</creatorcontrib><title>Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic</title><title>World journal of pediatrics : WJP</title><addtitle>World J Pediatr</addtitle><addtitle>World J Pediatr</addtitle><description>Background
The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods
All patients with KD admitted between February and April in 2015–2020, were classified into before (group 1, in 2015–2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (
n
= 98) and non-KD (
n
= 4644)] referred to
Mycoplasma pneumoniae
(MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results
Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion
Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>COVID-19 - epidemiology</subject><subject>Critical Care Medicine</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Infant</subject><subject>Intensive</subject><subject>Male</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mucocutaneous Lymph Node Syndrome - epidemiology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pandemics</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Physical Distancing</subject><subject>Pneumonia, Mycoplasma - epidemiology</subject><subject>Radiology</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>Surgery</subject><subject>Virus Diseases - epidemiology</subject><subject>Virus Diseases - virology</subject><issn>1708-8569</issn><issn>1867-0687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UcFu1DAUtBAVLYUf4IB842R4duI4uSChpUBFpV6Aq_V4dnbdzdorO0vVfj0ugUIvHJ7ekzwzHs0w9kLCawlg3hSptBwEKCkA2kYK9YidyL4zArrePK63gV70uhuO2dNSrgA6JTt4wo6btm5j4IRtV1OIgXDitMGMNPscyhyo8DTyz3iNBbeBu1A8Fs8xOk4p0iFnH2e-x3mT1j4W7g45xDUPJU04hxR5iHx1-e38vZBDhUXnd4GesaMRp-Kf_96n7OuHsy-rT-Li8uP56t2FoNb0s5BASpNxnjRqNN4pI7VH0tp01BKAb9XYDJ481BnNoF3Xkm-GsZPOadOcsreL7v7wfecdVasZJ7vPYYf5xiYM9uFLDBu7Tj9sr-Rg-qYKvFoErjGOGNf2Kh1yrJZtKX57e6tq5NDUOCtSLUjKqZTsx_tfJNi7kuxSkq0M-6skqyrp5b_-7il_WqmAZgGU_V2sPv818B_Zn8ken_k</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Ding, Yue-Yue</creator><creator>Ren, Yan</creator><creator>Qin, Jie</creator><creator>Qian, Guang-Hui</creator><creator>Tang, Yun-Jia</creator><creator>Chen, Ye</creator><creator>Li, Xuan</creator><creator>Xu, Lei</creator><creator>Qiao, Chun-Hong</creator><creator>Sun, Ling</creator><creator>Lv, Hai-Tao</creator><general>Springer Singapore</general><general>Cardiology Department,Children's Hospital of Soochow University,Suzhou 215025,China%Department of Radiology,Huashan Hospital of Fudan University,12 Mid Wulumuqi Road,Shanghai 200040,China%Institute of Pediatric Research,Children's Hospital of Soochow University,Suzhou 215025,China%Department of Biostatistics and Computational Biology,School of Life Science,Fudan University,Shanghai 200433,China</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5993-9248</orcidid></search><sort><creationdate>20210601</creationdate><title>Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic</title><author>Ding, Yue-Yue ; Ren, Yan ; Qin, Jie ; Qian, Guang-Hui ; Tang, Yun-Jia ; Chen, Ye ; Li, Xuan ; Xu, Lei ; Qiao, Chun-Hong ; Sun, Ling ; Lv, Hai-Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-10c25c7dec5a5a7ed2715eac5576c4c00e42f39ece0ecef795d64ce39f61dd573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>COVID-19 - epidemiology</topic><topic>Critical Care Medicine</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging</topic><topic>Incidence</topic><topic>Infant</topic><topic>Intensive</topic><topic>Male</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mucocutaneous Lymph Node Syndrome - epidemiology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pandemics</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Physical Distancing</topic><topic>Pneumonia, Mycoplasma - epidemiology</topic><topic>Radiology</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>Surgery</topic><topic>Virus Diseases - epidemiology</topic><topic>Virus Diseases - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Yue-Yue</creatorcontrib><creatorcontrib>Ren, Yan</creatorcontrib><creatorcontrib>Qin, Jie</creatorcontrib><creatorcontrib>Qian, Guang-Hui</creatorcontrib><creatorcontrib>Tang, Yun-Jia</creatorcontrib><creatorcontrib>Chen, Ye</creatorcontrib><creatorcontrib>Li, Xuan</creatorcontrib><creatorcontrib>Xu, Lei</creatorcontrib><creatorcontrib>Qiao, Chun-Hong</creatorcontrib><creatorcontrib>Sun, Ling</creatorcontrib><creatorcontrib>Lv, Hai-Tao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of pediatrics : WJP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Yue-Yue</au><au>Ren, Yan</au><au>Qin, Jie</au><au>Qian, Guang-Hui</au><au>Tang, Yun-Jia</au><au>Chen, Ye</au><au>Li, Xuan</au><au>Xu, Lei</au><au>Qiao, Chun-Hong</au><au>Sun, Ling</au><au>Lv, Hai-Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic</atitle><jtitle>World journal of pediatrics : WJP</jtitle><stitle>World J Pediatr</stitle><addtitle>World J Pediatr</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>17</volume><issue>3</issue><spage>263</spage><epage>271</epage><pages>263-271</pages><issn>1708-8569</issn><eissn>1867-0687</eissn><abstract>Background
The aim of this study is to explore the characteristics of Kawasaki disease (KD) and concurrent pathogens due to a stay-at-home isolation policy during coronavirus disease 2019 (COVID-19) epidemic.
Methods
All patients with KD admitted between February and April in 2015–2020, were classified into before (group 1, in 2015–2019) and after (group 2, in 2020) isolation groups. A total of 4742 patients [with KD (
n
= 98) and non-KD (
n
= 4644)] referred to
Mycoplasma pneumoniae
(MP) and virus detection were analyzed in 2020. Clinical characteristics, laboratory data, and 13 pathogens were analyzed retrospectively.
Results
Group 2 had a significantly increased incidence of KD (0.11%) with 107 patients compared to that of group 1 (0.03%) with 493 patients. The comparisons of oral mucosal change, strawberry tongue, desquamation of the fingertips, cervical lymphadenopathy and neutrophil percentage decreased in group 2 compared to group 1. The infection rate of MP increased significantly in group 2 (34.7%) compared to group 1 (19.3%), while the positive rate of viruses decreased significantly in group 2 (5.3%) compared to group 1 (14.3%). In 2020, the positive rate of MP infection increased significantly in patients with KD compared to the increase in patients with non-KD. The infection rate of MP for younger children aged less than 3 years old was higher in group 2 than in group 1.
Conclusion
Compared with the characteristics of KD from 2015 to 2019 years, the incidence of KD was increased in 2020 and was accompanied by a high incidence of MP infection, especially in younger children (less than 3 years old) during the isolation due to COVID-19 pandemic.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>34160770</pmid><doi>10.1007/s12519-021-00431-2</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5993-9248</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Child Child, Preschool COVID-19 - epidemiology Critical Care Medicine Female Humans Imaging Incidence Infant Intensive Male Maternal and Child Health Medicine Medicine & Public Health Mucocutaneous Lymph Node Syndrome - epidemiology Original Original Article Pandemics Pediatric Surgery Pediatrics Physical Distancing Pneumonia, Mycoplasma - epidemiology Radiology Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Retrospective Studies SARS-CoV-2 Surgery Virus Diseases - epidemiology Virus Diseases - virology |
| title | Clinical characteristics of Kawasaki disease and concurrent pathogens during isolation in COVID-19 pandemic |
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