Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)
Aims: Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to e...
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| Veröffentlicht in: | Journal of Atherosclerosis and Thrombosis 2021/06/01, Vol.28(6), pp.622-629 |
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| creator | Li, Yuting Cui, Renzhe Liu, Keyang Eshak, Ehab S. Cui, Meishan Dong, Jiayi Imano, Hironori Muraki, Isao Kiyama, Masahiko Kitamura, Akihiko Okada, Takeo Yamagishi, Kazumasa Umesawa, Mitsumasa Ohira, Tetsuya Iso, Hiroyasu investigators, the CIRCS |
| description | Aims: Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relationship between endothelial dysfunction and the prevalence of CKD in the general Japanese population. Methods: We conducted a cross-sectional study of 1042 men and women aged 30–81 years in two communities under the Circulatory Risk in Communities Study between 2013 and 2017. Endothelial function was evaluated by percent change of brachial artery flow-mediated dilation (%FMD) before and after the cuff inflation. Results: Among the total 1042 participants, there were 62 cases of CKD (~6%). The multivariable odds ratios (ORs) (95% confidence intervals [CIs]) of CKD according to quartiles of %FMD were 2.02 (0.68–5.99), 3.56 (1.27–9.94), and 3.14 (1.10–8.93) for the third to lowest quartile compared with the highest %FMD quartile; p for trend=0.02. The respective multivariable ORs (95% CIs) of CKD in subjects without antihypertensive medication use (39 cases among 886 subjects) were 1.83 (0.46–7.33), 3.41 (0.92–12.61), and 4.60 (1.22–17.31); p for trend=0.01, and that for one-point decrement in %FMD was 1.16 (1.00–1.35); p for interaction with the status of antihypertensive medication use was 0.12. Conclusions: Our cross-sectional study suggested the relationship between endothelial dysfunction and the higher prevalence of CKD in the general Japanese population. |
| doi_str_mv | 10.5551/jat.56424 |
| format | Article |
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Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relationship between endothelial dysfunction and the prevalence of CKD in the general Japanese population. Methods: We conducted a cross-sectional study of 1042 men and women aged 30–81 years in two communities under the Circulatory Risk in Communities Study between 2013 and 2017. Endothelial function was evaluated by percent change of brachial artery flow-mediated dilation (%FMD) before and after the cuff inflation. Results: Among the total 1042 participants, there were 62 cases of CKD (~6%). The multivariable odds ratios (ORs) (95% confidence intervals [CIs]) of CKD according to quartiles of %FMD were 2.02 (0.68–5.99), 3.56 (1.27–9.94), and 3.14 (1.10–8.93) for the third to lowest quartile compared with the highest %FMD quartile; p for trend=0.02. The respective multivariable ORs (95% CIs) of CKD in subjects without antihypertensive medication use (39 cases among 886 subjects) were 1.83 (0.46–7.33), 3.41 (0.92–12.61), and 4.60 (1.22–17.31); p for trend=0.01, and that for one-point decrement in %FMD was 1.16 (1.00–1.35); p for interaction with the status of antihypertensive medication use was 0.12. Conclusions: Our cross-sectional study suggested the relationship between endothelial dysfunction and the higher prevalence of CKD in the general Japanese population.</description><identifier>ISSN: 1340-3478</identifier><identifier>EISSN: 1880-3873</identifier><identifier>DOI: 10.5551/jat.56424</identifier><identifier>PMID: 32879150</identifier><language>eng</language><publisher>Japan: Japan Atherosclerosis Society</publisher><subject>Brachial Artery - physiopathology ; Cardiovascular System - physiopathology ; Chronic kidney disease ; Correlation of Data ; Cross-Sectional Studies ; Endothelial dysfunction ; Endothelium, Vascular - physiopathology ; Female ; General Japanese population ; Glomerular Filtration Rate ; Humans ; Japan - epidemiology ; Kidney - blood supply ; Male ; Middle Aged ; Original ; Renal Insufficiency, Chronic - mortality ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - therapy ; Risk Factors ; Vasodilation - physiology</subject><ispartof>Journal of Atherosclerosis and Thrombosis, 2021/06/01, Vol.28(6), pp.622-629</ispartof><rights>This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.</rights><rights>2021 Japan Atherosclerosis Society 2021</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c730t-36f9bad3685ec6cf7c910d6d978584fd4428a2191f01c6c899f77c451641c6b43</citedby><cites>FETCH-LOGICAL-c730t-36f9bad3685ec6cf7c910d6d978584fd4428a2191f01c6c899f77c451641c6b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219532/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219532/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1877,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32879150$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yuting</creatorcontrib><creatorcontrib>Cui, Renzhe</creatorcontrib><creatorcontrib>Liu, Keyang</creatorcontrib><creatorcontrib>Eshak, Ehab S.</creatorcontrib><creatorcontrib>Cui, Meishan</creatorcontrib><creatorcontrib>Dong, Jiayi</creatorcontrib><creatorcontrib>Imano, Hironori</creatorcontrib><creatorcontrib>Muraki, Isao</creatorcontrib><creatorcontrib>Kiyama, Masahiko</creatorcontrib><creatorcontrib>Kitamura, Akihiko</creatorcontrib><creatorcontrib>Okada, Takeo</creatorcontrib><creatorcontrib>Yamagishi, Kazumasa</creatorcontrib><creatorcontrib>Umesawa, Mitsumasa</creatorcontrib><creatorcontrib>Ohira, Tetsuya</creatorcontrib><creatorcontrib>Iso, Hiroyasu</creatorcontrib><creatorcontrib>investigators, the CIRCS</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>Fukushima Medical University</creatorcontrib><creatorcontrib>Dokkyo Medical University</creatorcontrib><creatorcontrib>Peking University Health Science Center</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><creatorcontrib>Osaka Center for Cancer and Cardiovascular Disease Prevention</creatorcontrib><creatorcontrib>Tokyo Metropolitan Institute of Gerontology</creatorcontrib><creatorcontrib>Department of Social Medicine</creatorcontrib><creatorcontrib>Department of Public Health Medicine</creatorcontrib><creatorcontrib>Radiation Medical Science Center for the Fukushima Health Management Survey</creatorcontrib><creatorcontrib>Public Health</creatorcontrib><creatorcontrib>Department of Public Health</creatorcontrib><creatorcontrib>Minia University</creatorcontrib><creatorcontrib>Department of Public Health and Community Medicine Department</creatorcontrib><creatorcontrib>and Health Services Research and Development Center</creatorcontrib><creatorcontrib>School of Public Health</creatorcontrib><creatorcontrib>CIRCS investigators</creatorcontrib><creatorcontrib>the CIRCS investigators</creatorcontrib><title>Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)</title><title>Journal of Atherosclerosis and Thrombosis</title><addtitle>JAT</addtitle><description>Aims: Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relationship between endothelial dysfunction and the prevalence of CKD in the general Japanese population. Methods: We conducted a cross-sectional study of 1042 men and women aged 30–81 years in two communities under the Circulatory Risk in Communities Study between 2013 and 2017. Endothelial function was evaluated by percent change of brachial artery flow-mediated dilation (%FMD) before and after the cuff inflation. Results: Among the total 1042 participants, there were 62 cases of CKD (~6%). The multivariable odds ratios (ORs) (95% confidence intervals [CIs]) of CKD according to quartiles of %FMD were 2.02 (0.68–5.99), 3.56 (1.27–9.94), and 3.14 (1.10–8.93) for the third to lowest quartile compared with the highest %FMD quartile; p for trend=0.02. The respective multivariable ORs (95% CIs) of CKD in subjects without antihypertensive medication use (39 cases among 886 subjects) were 1.83 (0.46–7.33), 3.41 (0.92–12.61), and 4.60 (1.22–17.31); p for trend=0.01, and that for one-point decrement in %FMD was 1.16 (1.00–1.35); p for interaction with the status of antihypertensive medication use was 0.12. Conclusions: Our cross-sectional study suggested the relationship between endothelial dysfunction and the higher prevalence of CKD in the general Japanese population.</description><subject>Brachial Artery - physiopathology</subject><subject>Cardiovascular System - physiopathology</subject><subject>Chronic kidney disease</subject><subject>Correlation of Data</subject><subject>Cross-Sectional Studies</subject><subject>Endothelial dysfunction</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>General Japanese population</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Kidney - blood supply</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Renal Insufficiency, Chronic - mortality</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Renal Insufficiency, Chronic - therapy</subject><subject>Risk Factors</subject><subject>Vasodilation - physiology</subject><issn>1340-3478</issn><issn>1880-3873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9u1DAQxiMEoqVw4AWQj-1hi_8lsTlQobSUikqgtpwtrzNpvDj2YieFvAGPjXe3rOAyM9Z8-s0nf0XxmuDTsizJ25UeT8uKU_6kOCRC4AUTNXuaZ8bzzGtxULxIaYUxY2VJnxcHjIpakhIfFr9vwOnRBp96u0ZLGH8CeHTh2zD24Kx26HxO3eTNRoO0b9HXCA_agTeAQoeaPgZvDfpsWw8zOrcJdIJ36K4H1NhopkwPcUY3Nn1H1qMmDMPk7Wghodtxamd03FzdNLcnL4tnnXYJXj32o-Lbx4u75tPi-svlVfPhemFqhscFqzq51C2rRAmmMl1tJMFt1cpalIJ3LedUaEok6TDJeyFlV9eGl6Ti-b3k7Kh4v-Oup-UArQE_Ru3UOtpBx1kFbdX_G297dR8elMjUktEMOH4ExPBjgjSqwSYDzmkPYUqKcialIIKzLD3ZSU0MKUXo9mcIVpvkVE5ObZPL2jf_-tor_0aVBZc7Qd5ao13wznpQqzBFnz9Mwa-6DcOsFcWUKIypwFVuUuGK0k2RLLtilcyksx1plUZ9D_tTOo7WONiaokJVm7I1t9-YXkcFnv0BO8_DYQ</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Li, Yuting</creator><creator>Cui, Renzhe</creator><creator>Liu, Keyang</creator><creator>Eshak, Ehab S.</creator><creator>Cui, Meishan</creator><creator>Dong, Jiayi</creator><creator>Imano, Hironori</creator><creator>Muraki, Isao</creator><creator>Kiyama, Masahiko</creator><creator>Kitamura, Akihiko</creator><creator>Okada, Takeo</creator><creator>Yamagishi, Kazumasa</creator><creator>Umesawa, Mitsumasa</creator><creator>Ohira, Tetsuya</creator><creator>Iso, Hiroyasu</creator><creator>investigators, the CIRCS</creator><general>Japan Atherosclerosis Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210601</creationdate><title>Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)</title><author>Li, Yuting ; Cui, Renzhe ; Liu, Keyang ; Eshak, Ehab S. ; Cui, Meishan ; Dong, Jiayi ; Imano, Hironori ; Muraki, Isao ; Kiyama, Masahiko ; Kitamura, Akihiko ; Okada, Takeo ; Yamagishi, Kazumasa ; Umesawa, Mitsumasa ; Ohira, Tetsuya ; Iso, Hiroyasu ; investigators, the CIRCS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c730t-36f9bad3685ec6cf7c910d6d978584fd4428a2191f01c6c899f77c451641c6b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brachial Artery - physiopathology</topic><topic>Cardiovascular System - physiopathology</topic><topic>Chronic kidney disease</topic><topic>Correlation of Data</topic><topic>Cross-Sectional Studies</topic><topic>Endothelial dysfunction</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>General Japanese population</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Kidney - blood supply</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Renal Insufficiency, Chronic - mortality</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Renal Insufficiency, Chronic - therapy</topic><topic>Risk Factors</topic><topic>Vasodilation - physiology</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Yuting</creatorcontrib><creatorcontrib>Cui, Renzhe</creatorcontrib><creatorcontrib>Liu, Keyang</creatorcontrib><creatorcontrib>Eshak, Ehab S.</creatorcontrib><creatorcontrib>Cui, Meishan</creatorcontrib><creatorcontrib>Dong, Jiayi</creatorcontrib><creatorcontrib>Imano, Hironori</creatorcontrib><creatorcontrib>Muraki, Isao</creatorcontrib><creatorcontrib>Kiyama, Masahiko</creatorcontrib><creatorcontrib>Kitamura, Akihiko</creatorcontrib><creatorcontrib>Okada, Takeo</creatorcontrib><creatorcontrib>Yamagishi, Kazumasa</creatorcontrib><creatorcontrib>Umesawa, Mitsumasa</creatorcontrib><creatorcontrib>Ohira, Tetsuya</creatorcontrib><creatorcontrib>Iso, Hiroyasu</creatorcontrib><creatorcontrib>investigators, the CIRCS</creatorcontrib><creatorcontrib>Osaka University Graduate School of Medicine</creatorcontrib><creatorcontrib>Faculty of Medicine</creatorcontrib><creatorcontrib>School of Medicine</creatorcontrib><creatorcontrib>Fukushima Medical University</creatorcontrib><creatorcontrib>Dokkyo Medical University</creatorcontrib><creatorcontrib>Peking University Health Science Center</creatorcontrib><creatorcontrib>University of Tsukuba</creatorcontrib><creatorcontrib>Osaka Center for Cancer and Cardiovascular Disease Prevention</creatorcontrib><creatorcontrib>Tokyo Metropolitan Institute of Gerontology</creatorcontrib><creatorcontrib>Department of Social Medicine</creatorcontrib><creatorcontrib>Department of Public Health Medicine</creatorcontrib><creatorcontrib>Radiation Medical Science Center for the Fukushima Health Management Survey</creatorcontrib><creatorcontrib>Public Health</creatorcontrib><creatorcontrib>Department of Public Health</creatorcontrib><creatorcontrib>Minia University</creatorcontrib><creatorcontrib>Department of Public Health and Community Medicine Department</creatorcontrib><creatorcontrib>and Health Services Research and Development Center</creatorcontrib><creatorcontrib>School of Public Health</creatorcontrib><creatorcontrib>CIRCS investigators</creatorcontrib><creatorcontrib>the CIRCS investigators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yuting</au><au>Cui, Renzhe</au><au>Liu, Keyang</au><au>Eshak, Ehab S.</au><au>Cui, Meishan</au><au>Dong, Jiayi</au><au>Imano, Hironori</au><au>Muraki, Isao</au><au>Kiyama, Masahiko</au><au>Kitamura, Akihiko</au><au>Okada, Takeo</au><au>Yamagishi, Kazumasa</au><au>Umesawa, Mitsumasa</au><au>Ohira, Tetsuya</au><au>Iso, Hiroyasu</au><au>investigators, the CIRCS</au><aucorp>Osaka University Graduate School of Medicine</aucorp><aucorp>Faculty of Medicine</aucorp><aucorp>School of Medicine</aucorp><aucorp>Fukushima Medical University</aucorp><aucorp>Dokkyo Medical University</aucorp><aucorp>Peking University Health Science Center</aucorp><aucorp>University of Tsukuba</aucorp><aucorp>Osaka Center for Cancer and Cardiovascular Disease Prevention</aucorp><aucorp>Tokyo Metropolitan Institute of Gerontology</aucorp><aucorp>Department of Social Medicine</aucorp><aucorp>Department of Public Health Medicine</aucorp><aucorp>Radiation Medical Science Center for the Fukushima Health Management Survey</aucorp><aucorp>Public Health</aucorp><aucorp>Department of Public Health</aucorp><aucorp>Minia University</aucorp><aucorp>Department of Public Health and Community Medicine Department</aucorp><aucorp>and Health Services Research and Development Center</aucorp><aucorp>School of Public Health</aucorp><aucorp>CIRCS investigators</aucorp><aucorp>the CIRCS investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS)</atitle><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle><addtitle>JAT</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>28</volume><issue>6</issue><spage>622</spage><epage>629</epage><pages>622-629</pages><issn>1340-3478</issn><eissn>1880-3873</eissn><abstract>Aims: Patients with chronic kidney disease (CKD) have a higher burden of cardiovascular morbidity and mortality than the general population. Endothelial dysfunction has been suggested to play a role in both glomerular filtration rate loss and cardiovascular damage. Thus, the present study aimed to evaluate the relationship between endothelial dysfunction and the prevalence of CKD in the general Japanese population. Methods: We conducted a cross-sectional study of 1042 men and women aged 30–81 years in two communities under the Circulatory Risk in Communities Study between 2013 and 2017. Endothelial function was evaluated by percent change of brachial artery flow-mediated dilation (%FMD) before and after the cuff inflation. Results: Among the total 1042 participants, there were 62 cases of CKD (~6%). The multivariable odds ratios (ORs) (95% confidence intervals [CIs]) of CKD according to quartiles of %FMD were 2.02 (0.68–5.99), 3.56 (1.27–9.94), and 3.14 (1.10–8.93) for the third to lowest quartile compared with the highest %FMD quartile; p for trend=0.02. The respective multivariable ORs (95% CIs) of CKD in subjects without antihypertensive medication use (39 cases among 886 subjects) were 1.83 (0.46–7.33), 3.41 (0.92–12.61), and 4.60 (1.22–17.31); p for trend=0.01, and that for one-point decrement in %FMD was 1.16 (1.00–1.35); p for interaction with the status of antihypertensive medication use was 0.12. Conclusions: Our cross-sectional study suggested the relationship between endothelial dysfunction and the higher prevalence of CKD in the general Japanese population.</abstract><cop>Japan</cop><pub>Japan Atherosclerosis Society</pub><pmid>32879150</pmid><doi>10.5551/jat.56424</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Atherosclerosis and Thrombosis, 2021/06/01, Vol.28(6), pp.622-629 |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Brachial Artery - physiopathology Cardiovascular System - physiopathology Chronic kidney disease Correlation of Data Cross-Sectional Studies Endothelial dysfunction Endothelium, Vascular - physiopathology Female General Japanese population Glomerular Filtration Rate Humans Japan - epidemiology Kidney - blood supply Male Middle Aged Original Renal Insufficiency, Chronic - mortality Renal Insufficiency, Chronic - physiopathology Renal Insufficiency, Chronic - therapy Risk Factors Vasodilation - physiology |
| title | Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS) |
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