Metformin in Combination with Malvidin Prevents Progression of Non-Alcoholic Fatty Liver Disease via Improving Lipid and Glucose Metabolisms, and Inhibiting Inflammation in Type 2 Diabetes Rats

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the primary causes of chronic liver disease and is closely linked to insulin resistance, type 2 diabetes mellitus (T2DM), and dyslipidemia. However, no effective drug therapies have been approved to treat this disease. The present resea...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2021-01, Vol.15, p.2565-2576
Hauptverfasser:	Zou, Wenlan, Zhang, Chen, Gu, Xuefang, Li, Xiaohong, Zhu, Huiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthocyanins - administration & dosage Anthocyanins - pharmacology Antidiabetics Bioengineering Chemistry, Medicinal Cholesterol Dextrose Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes therapy Disease Progression Drug approval Drug therapy Drug Therapy, Combination Dyslipidemia Experiments Fatty liver Gene expression Glucose Glucose - metabolism Health aspects Hyperglycemia Hyperlipidemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Inflammation Inflammation - drug therapy Inflammation - pathology Insulin Insulin Resistance Interleukin 6 Interleukin 8 Laboratory animals Life Sciences & Biomedicine Lipid Metabolism - drug effects Lipids Liver Liver cancer Liver diseases Male Medical research Medicine, Experimental Metabolism Metformin Metformin - administration & dosage Metformin - pharmacology mRNA Natural products NF-κB protein Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - physiopathology Original Research Pharmacology & Pharmacy Physiological aspects Physiology Rats Rats, Sprague-Dawley Reagents Science & Technology Sterol regulatory element-binding protein Type 2 diabetes Variance analysis
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