Developments of Subunit and VLP Vaccines Against Influenza A Virus
Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and eco...
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| Veröffentlicht in: | Virologica Sinica 2012-06, Vol.27 (3), p.145-153 |
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| creator | Deng, Ma-ping Hu, Zhi-hong Wang, Hua-lin Deng, Fei |
| description | Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines. |
| doi_str_mv | 10.1007/s12250-012-3241-1 |
| format | Article |
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The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines.</description><identifier>ISSN: 1674-0769</identifier><identifier>EISSN: 1995-820X</identifier><identifier>DOI: 10.1007/s12250-012-3241-1</identifier><identifier>PMID: 22684468</identifier><language>eng</language><publisher>Heidelberg: Springer-Verlag</publisher><subject>Antigens ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Biotechnology - methods ; Biotechnology - trends ; Economics ; Exo- alpha -sialidase ; Exo-a-sialidase ; Hemagglutinins ; Humans ; Influenza ; Influenza A ; Influenza A virus ; Influenza Vaccines - genetics ; Influenza Vaccines - immunology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Medical Microbiology ; Microbial Genetics and Genomics ; Microbiology ; nucleocapsid ; Nucleocapsids ; Oncology ; Orthomyxoviridae - genetics ; Orthomyxoviridae - immunology ; Recombinant DNA ; research and development ; sialidase ; Technology, Pharmaceutical - methods ; Technology, Pharmaceutical - trends ; Vaccines ; Vaccines, Subunit - genetics ; Vaccines, Subunit - immunology ; Vaccines, Synthetic - genetics ; Vaccines, Synthetic - immunology ; Vaccines, Virosome - genetics ; Vaccines, Virosome - immunology ; Viral Proteins - genetics ; Viral Proteins - immunology ; Virology ; virus-like particle vaccines ; 亚基 ; 抗流感病毒 ; 核衣壳蛋白 ; 流感疫苗 ; 病毒样颗粒 ; 神经氨酸酶 ; 经济损失 ; 重组DNA技术</subject><ispartof>Virologica Sinica, 2012-06, Vol.27 (3), p.145-153</ispartof><rights>Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2012</rights><rights>Wuhan Institute of Virology, CAS and Springer-Verlag Berlin Heidelberg 2012.</rights><rights>Copyright © Wanfang Data Co. 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Sin</addtitle><addtitle>Virologica Sinica</addtitle><description>Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). It would help to get insight into the current stage of influenza vaccines, and suggest the future design and development of novel influenza vaccines.</description><subject>Antigens</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology - methods</subject><subject>Biotechnology - trends</subject><subject>Economics</subject><subject>Exo- alpha -sialidase</subject><subject>Exo-a-sialidase</subject><subject>Hemagglutinins</subject><subject>Humans</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A virus</subject><subject>Influenza Vaccines - genetics</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Medical Microbiology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>nucleocapsid</subject><subject>Nucleocapsids</subject><subject>Oncology</subject><subject>Orthomyxoviridae - genetics</subject><subject>Orthomyxoviridae - immunology</subject><subject>Recombinant DNA</subject><subject>research and development</subject><subject>sialidase</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Technology, Pharmaceutical - trends</subject><subject>Vaccines</subject><subject>Vaccines, Subunit - genetics</subject><subject>Vaccines, Subunit - immunology</subject><subject>Vaccines, Synthetic - genetics</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Vaccines, Virosome - genetics</subject><subject>Vaccines, Virosome - immunology</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - immunology</subject><subject>Virology</subject><subject>virus-like particle vaccines</subject><subject>亚基</subject><subject>抗流感病毒</subject><subject>核衣壳蛋白</subject><subject>流感疫苗</subject><subject>病毒样颗粒</subject><subject>神经氨酸酶</subject><subject>经济损失</subject><subject>重组DNA技术</subject><issn>1674-0769</issn><issn>1995-820X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAUjBCIlsIP4AJBSIhL4PnZ649LpaV8VVoJpNIVN8t2nDRV1t7GmwL99XjJsnwcECdbevNmxjMuiocEXhAA8TIRxBlUQLCiyEhFbhWHRKlZJRE-3853LlgFgquD4l5KlwAcJaV3iwNELhnj8rB49dpf-z6uVz5sUhmb8my0Y-g2pQl1uVx8LJfGuS74VM5b04W0KU9D048-3JhyXi67YUz3izuN6ZN_sDuPivO3bz6dvK8WH96dnswXlWNKkYozJyx4DpZxWysmZ8o0YmbBKuuo8LXxzjMuvCFonadIas-lkqaRtgaq6FFxPPGuR7vytcuOB9Pr9dCtzPBNR9PpPyehu9BtvNYSiQQqM8GzieCLCY0Jrb6M4xCyZX3T2vor5hyBApAMfL5TGuLV6NNGr7rkfN-b4OOYNAHMhMiB_g8UICctZhn69C_oXh8ZUEKE-KFNJpQbYkqDb_YPJKC3reupdZ3d6m3rervz6Pdk9hs_a84AnAApj0Lrh1_S_2J9PC01JmrTDl3S52c5JAb5I3FEkRFPdl4vYmivMvNemiFBhYLQ7ypIyh0</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Deng, Ma-ping</creator><creator>Hu, Zhi-hong</creator><creator>Wang, Hua-lin</creator><creator>Deng, Fei</creator><general>Springer-Verlag</general><general>SP Wuhan Institute of Virology, CAS</general><general>KeAi Publishing Communications Ltd</general><general>State Key Laboratory of Virology and Joint-Lab of Invertebrate Virology,Chinese Virus Resource and Bioinformatics Center,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>201206</creationdate><title>Developments of Subunit and VLP Vaccines Against Influenza A Virus</title><author>Deng, Ma-ping ; 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Sin</stitle><addtitle>Virologica Sinica</addtitle><date>2012-06</date><risdate>2012</risdate><volume>27</volume><issue>3</issue><spage>145</spage><epage>153</epage><pages>145-153</pages><issn>1674-0769</issn><eissn>1995-820X</eissn><abstract>Influenza virus is a continuous and severe global threat to mankind. The continuously re-emerging disease gives rise to thousands of deaths and enormous economic losses each year, which emphasizes the urgency and necessity to develop high-quality influenza vaccines in a safer, more efficient and economic way. The influenza subunit and VLP vaccines, taking the advantage of recombinant DNA technologies and expression system platforms, can be produced in such an ideal way. This review summarized the recent advancements in the research and development of influenza subunit and VLP vaccines based on the recombinant expression of hemagglutinin antigen (HA), neuraminidase antigen (NA), Matrix 2 protein (M2) and nucleocapsid protein (NP). 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| fulltext | fulltext |
| identifier | ISSN: 1674-0769 |
| ispartof | Virologica Sinica, 2012-06, Vol.27 (3), p.145-153 |
| issn | 1674-0769 1995-820X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8218038 |
| source | MEDLINE; SpringerLink Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antigens Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology - methods Biotechnology - trends Economics Exo- alpha -sialidase Exo-a-sialidase Hemagglutinins Humans Influenza Influenza A Influenza A virus Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza, Human - immunology Influenza, Human - prevention & control Medical Microbiology Microbial Genetics and Genomics Microbiology nucleocapsid Nucleocapsids Oncology Orthomyxoviridae - genetics Orthomyxoviridae - immunology Recombinant DNA research and development sialidase Technology, Pharmaceutical - methods Technology, Pharmaceutical - trends Vaccines Vaccines, Subunit - genetics Vaccines, Subunit - immunology Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccines, Virosome - genetics Vaccines, Virosome - immunology Viral Proteins - genetics Viral Proteins - immunology Virology virus-like particle vaccines 亚基 抗流感病毒 核衣壳蛋白 流感疫苗 病毒样颗粒 神经氨酸酶 经济损失 重组DNA技术 |
| title | Developments of Subunit and VLP Vaccines Against Influenza A Virus |
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