E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer

Central precocious puberty (CPP), largely caused by germline mutations in the MKRN3 gene, has been epidemiologically linked to cancers. MKRN3 is frequently mutated in non-small cell lung cancers (NSCLCs) with five cohorts. Genomic MKRN3 aberrations are significantly enriched in NSCLC samples harbori...

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Veröffentlicht in:	The Journal of experimental medicine 2021-08, Vol.218 (8)
Hauptverfasser:	Li, Ke, Zheng, Xufen, Tang, Hua, Zang, Yuan-Sheng, Zeng, Chunling, Liu, Xiaoxiao, Shen, Yanying, Pang, Yuzhi, Wang, Simin, Xie, Feifei, Lu, Xiaojing, Luo, Yuxiang, Li, Zhang, Bi, Wenbo, Jia, Xiaona, Huang, Tao, Wei, Rongqiang, Huang, Kenan, Chen, Zihao, Zhu, Qingchen, He, Yi, Zhang, Miaoying, Gu, Zhizhan, Xiao, Yichuan, Zhang, Xiaoyang, Fletcher, Jonathan A, Wang, Yuexiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carcinogenesis - metabolism Carcinogenesis - pathology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation HEK293 Cells Human disease genetics Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Inbred C57BL Mice, Knockout Mutation - genetics Poly(A)-Binding Protein I - metabolism Protein Binding Protein Biosynthesis Proto-Oncogene Proteins p21(ras) - genetics Reproducibility of Results Solid Tumors Survival Analysis Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Urethane
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