The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase

Acetylcholinesterase (AChE) is an important drug target in neurological disorders like Alzheimer’s disease, Lewy body dementia, and Parkinson’s disease dementia as well as for other conditions like myasthenia gravis and anticholinergic poisoning. In this study, we have used a combination of high-thr...

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Veröffentlicht in:	Chemical research in toxicology 2021-05, Vol.34 (5), p.1296-1307
Hauptverfasser:	Vignaux, Patricia A, Minerali, Eni, Lane, Thomas R, Foil, Daniel H, Madrid, Peter B, Puhl, Ana C, Ekins, Sean
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Dose-Response Relationship, Drug Electrophorus Humans Machine Learning Molecular Docking Simulation Molecular Structure Structure-Activity Relationship Tilorone - chemistry Tilorone - pharmacology
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