Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling

GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical signaling activates GαS-mediated generation of cytosolic cAMP, has been shown to be necessary for the growth of glioblastoma (GBM), a brain malignancy. The extracellular N terminus of GPR133 is thought to be autoproteolyt...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100798-100798, Article 100798
Hauptverfasser:	Frenster, Joshua D., Stephan, Gabriele, Ravn-Boess, Niklas, Bready, Devin, Wilcox, Jordan, Kieslich, Bjoern, Wilde, Caroline, Sträter, Norbert, Wiggin, Giselle R., Liebscher, Ines, Schöneberg, Torsten, Placantonakis, Dimitris G.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion GPCR glioblastoma glycosylation intracellular trafficking intramolecular cleavage NTF–CTF dissociation receptor structure–function signaling subcellular fractionation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!