Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect
We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to...
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| Veröffentlicht in: | BMJ case reports 2021-06, Vol.14 (6), p.e243191 |
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| creator | Brandi, Sandra L Feltoft, Claus L Serup, Jørgen Eldrup, Ebbe |
| description | We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored. |
| doi_str_mv | 10.1136/bcr-2021-243191 |
| format | Article |
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Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2021-243191</identifier><identifier>PMID: 34144953</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Antifungal agents ; Antifungal Agents - adverse effects ; Blood pressure ; Case Report ; Case reports ; Clinical significance ; Dehydrogenases ; Drug-Related Side Effects and Adverse Reactions ; Enzymes ; Hormones ; Humans ; Hypertension ; Itraconazole - adverse effects ; Kidneys ; Metabolites ; Outpatient care facilities ; Patients ; Suffering ; Urine ; Voriconazole - adverse effects</subject><ispartof>BMJ case reports, 2021-06, Vol.14 (6), p.e243191</ispartof><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. 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Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.</description><subject>Antifungal agents</subject><subject>Antifungal Agents - adverse effects</subject><subject>Blood pressure</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Clinical significance</subject><subject>Dehydrogenases</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Enzymes</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Itraconazole - adverse effects</subject><subject>Kidneys</subject><subject>Metabolites</subject><subject>Outpatient care facilities</subject><subject>Patients</subject><subject>Suffering</subject><subject>Urine</subject><subject>Voriconazole - adverse effects</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1r3DAQxUVpaUKSc29F0FvBjUcfttVDoYR-QaA9JNCbkKXxrhZb2kpyYfvXR2HTkJ6qy4yYn9488Qh5Be07AN5djjY1rGXQMMFBwTNyCr3sm161P58_6U_IRc67th4OYhD8JTnhAoRQkp-S8CPj6uL2sMdkZhdzwRR9Xqhbkw8b6ksyNgbzJ85IS0JTFgzlPTV068sWU4k04GZGW9BRO_vgrZnnA81-E_xUL6HU3iHFaarQOXkxmTnjxUM9I7efP91cfW2uv3_5dvXxuhmF7ErDJwGTBAFMonS8t4PsW1BGobQ4tA5UB2xUzhjRdp01BvppVJ2woJjlYuBn5MNRd7-OCzpbPdfv6X3yi0kHHY3X_06C3-pN_K0HBpKJvgq8eRBI8deKuehdXFOonjWTgsmeMw6VujxSNsWcE06PG6DV9xnpmpG-z0gfM6ovXj819sj_TaQCb4_AuOz-q3YH0YKdQg</recordid><startdate>20210618</startdate><enddate>20210618</enddate><creator>Brandi, Sandra L</creator><creator>Feltoft, Claus L</creator><creator>Serup, Jørgen</creator><creator>Eldrup, Ebbe</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1483-8889</orcidid></search><sort><creationdate>20210618</creationdate><title>Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect</title><author>Brandi, Sandra L ; 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Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>34144953</pmid><doi>10.1136/bcr-2021-243191</doi><orcidid>https://orcid.org/0000-0002-1483-8889</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antifungal agents Antifungal Agents - adverse effects Blood pressure Case Report Case reports Clinical significance Dehydrogenases Drug-Related Side Effects and Adverse Reactions Enzymes Hormones Humans Hypertension Itraconazole - adverse effects Kidneys Metabolites Outpatient care facilities Patients Suffering Urine Voriconazole - adverse effects |
| title | Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect |
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