Prediction of Acute Graft versus Host Disease and Relapse by Endogenous Metabolomic Compounds in Patients Receiving Personalized Busulfan-Based Conditioning

Busulfan-based conditioning is the most commonly used high-dose conditioning regimen for allogeneic hematopoietic cell transplant (HCT). The alkylating agent busulfan has a narrow therapeutic index, with busulfan doses personalized to a target plasma exposure (targeted busulfan). Using a global phar...

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Veröffentlicht in:	Journal of proteome research 2021-01, Vol.20 (1), p.684-694
Hauptverfasser:	McCune, Jeannine S, McKiernan, Jožefa S, van Maarseveen, Erik, Huitema, Alwin D. R, Randolph, Timothy W, Deeg, H. Joachim, Nakamura, Ryotaro, Baker, K. Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Busulfan - therapeutic use Graft vs Host Disease - diagnosis Hematopoietic Stem Cell Transplantation Humans Metabolomics Prognosis Recurrence Transplantation Conditioning Vidarabine
Online-Zugang:	Volltext
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