Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir

Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that are otherwise occluded on the unliganded viral envelope (Env). Combining CD4mc with two families of CD4-induced (CD4i) antibodie...

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Veröffentlicht in:	Cell host & microbe 2021-06, Vol.29 (6), p.904-916.e6
Hauptverfasser:	Rajashekar, Jyothi K., Richard, Jonathan, Beloor, Jagadish, Prévost, Jérémie, Anand, Sai Priya, Beaudoin-Bussières, Guillaume, Shan, Liang, Herndler-Brandstetter, Dietmar, Gendron-Lepage, Gabrielle, Medjahed, Halima, Bourassa, Catherine, Gaudette, Fleur, Ullah, Irfan, Symmes, Kelly, Peric, Andrew, Lindemuth, Emily, Bibollet-Ruche, Frederic, Park, Jun, Chen, Hung-Ching, Kaufmann, Daniel E., Hahn, Beatrice H., Sodroski, Joseph, Pazgier, Marzena, Flavell, Richard A., Smith, Amos B., Finzi, Andrés, Kumar, Priti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - therapeutic use Antibody-Dependent Cell Cytotoxicity antibody-dependent cellular cytotoxicity Antiviral Agents - therapeutic use CD4 Antigens - chemistry CD4 Antigens - metabolism CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - virology CD4i Abs Cell Line env Gene Products, Human Immunodeficiency Virus - chemistry env Gene Products, Human Immunodeficiency Virus - immunology envelope glycoprotein Epitopes - immunology Female Glycoproteins - chemistry Glycoproteins - immunology HEK293 Cells HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 HIV-1 - chemistry HIV-1 - drug effects HIV-1 - immunology humanized mice Humans Immunoglobulin Fc Fragments - immunology Killer Cells, Natural - immunology Male Mice Mice, SCID Models, Animal NK cell Protein Conformation SRG-15 State 2A Virus Replication - drug effects
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