Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts

Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) have emerged as an exciting new tool for cardiac research and can serve as a preclinical platform for drug development and disease modeling studies. However, these aspirations are limited by current culture methods in which hPSC‐CMs resem...

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Veröffentlicht in:	Biotechnology and bioengineering 2021-01, Vol.118 (1), p.442-452
Hauptverfasser:	Napiwocki, B. N., Lang, D., Stempien, A., Zhang, J., Vaidyanathan, R., Makielski, J. C., Eckhardt, L. L., Glukhov, A. V., Kamp, T. J., Crone, W. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	anisotropic conduction Biomimetics Cardiomyocytes Cardiovascular diseases Cell culture Cell Line Construction Coronary artery disease Drug development Electric bridges Electric pulses Electrophysiological Phenomena Extracellular matrix Fetuses Giant Cells - metabolism Heart diseases human pluripotent stem cell‐derived cardiomyocytes Humans Induced Pluripotent Stem Cells - metabolism Mechanical properties microcontact printing Micropatterning Myocardium Myocardium - metabolism Myocytes, Cardiac - metabolism Pharmacovigilance Pluripotency Propagation Stem cells Stiffness Structure-function relationships substrate stiffness Substrates Toxins
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