Platelets as messengers of early-stage cancer
Platelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for b...
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| Veröffentlicht in: | Cancer and metastasis reviews 2021-06, Vol.40 (2), p.563-573 |
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| container_title | Cancer and metastasis reviews |
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| creator | Sabrkhany, Siamack Kuijpers, Marijke J. E. oude Egbrink, Mirjam G. A. Griffioen, Arjan W. |
| description | Platelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages. |
| doi_str_mv | 10.1007/s10555-021-09956-4 |
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| ispartof | Cancer and metastasis reviews, 2021-06, Vol.40 (2), p.563-573 |
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| language | eng |
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| subjects | Analysis Angiogenesis Animals Biomedical and Life Sciences Biomedicine Blood Blood Platelets - pathology Cancer Cancer Research Cell Growth Processes - physiology Clopidogrel Diagnosis Hematologic Tests - methods Humans Medical centers Medical examination Metastases Metastasis mRNA Neoplasm Metastasis Neoplasm Staging Neoplasms - blood Neoplasms - blood supply Neoplasms - diagnosis Neoplasms - pathology Neovascularization, Pathologic - blood Neovascularization, Pathologic - pathology Non-Thematic Review Oncology Oncology, Experimental Physiological aspects Platelets |
| title | Platelets as messengers of early-stage cancer |
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