Caspase-1-Inhibitor AC-YVAD-CMK Inhibits Pyroptosis and Ameliorates Acute Kidney Injury in a Model of Sepsis

Objective. To observe the protective effect of AC-YVAD-CMK on sepsis-induced acute kidney injury in mice and to explore its possible mechanisms primarily. Methods. Eighteen male C57BL/6 mice were randomly divided into sham-operated group (Control), cecal ligation and puncture group (CLP), and CLP mo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	BioMed research international 2021, Vol.2021, p.6636621-9
Hauptverfasser:	Yang, Mei, Fang, Jin-tao, Zhang, Ni-shang, Qin, Long-jiang, Zhuang, Yang-yang, Wang, Wei-wei, Zhu, Hai-ping, Zhang, Yan-jie, Xia, Peng, Zhang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - drug therapy Acute Kidney Injury - metabolism Acute renal failure Amino Acid Chloromethyl Ketones - pharmacology Analysis Animals Antigens, CD - biosynthesis Antigens, Differentiation, Myelomonocytic - biosynthesis Apoptosis Attenuation Bioaccumulation Biotechnology Blood Blood Urea Nitrogen Care and treatment Caspase 1 - metabolism Caspase Inhibitors - pharmacology Caspase-1 Cecum Creatinine Cytokines Cytokines - metabolism Diagnosis Dosage and administration Enzyme-linked immunosorbent assay Heart rate Identification and classification IL-1β Immunofluorescence Immunohistochemistry Infections Inflammation Inhibitor of apoptosis proteins Inhibitors Injuries Interleukin 18 Interleukin 6 Interleukin-18 - biosynthesis Interleukin-1beta - biosynthesis Interleukin-6 - biosynthesis Interleukins Kidney - metabolism Kidneys Laboratory animals Leukocytes (neutrophilic) Ly-6 antigen Macrophages Macrophages - metabolism Male Methods Mice Mice, Inbred C57BL Monoclonal antibodies Neutrophils - metabolism Polyclonal antibodies Proteins Pyroptosis Pyroptosis - drug effects Risk factors Sepsis Sepsis - drug therapy Sepsis - metabolism Serum levels Staining Surgery Tissues Tumor necrosis factor-α Urea
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!