Nonlinear gene expression‐phenotype relationships contribute to variation and clefting in the A/WySn mouse

Background Cleft lip and palate is one of the most common human birth defects, but the underlying etiology is poorly understood. The A/WySn mouse is a spontaneously occurring model of multigenic clefting in which 20% to 30% of individuals develop an orofacial cleft. Recent work has shown altered met...

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Veröffentlicht in:	Developmental dynamics 2019-12, Vol.248 (12), p.1232-1242
Hauptverfasser:	Green, Rebecca M., Leach, Courtney L., Diewert, Virginia M., Aponte, Jose David, Schmidt, Eric J., Cheverud, James M., Roseman, Charles C., Young, Nathan M., Marcucio, Ralph S., Hallgrimsson, Benedikt
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Variation, Individual Birth defects CL/P Cleft Lip - complications Cleft Lip - genetics Cleft Lip - pathology Cleft lip/palate Cleft Palate - complications Cleft Palate - genetics Cleft Palate - pathology Congenital defects Deoxyribonucleic acid Disease Models, Animal DNA DNA Methylation Embryo, Mammalian Embryos Etiology Face - embryology Face - pathology facial development Gene expression Gene Expression Regulation, Developmental - physiology Genetic Association Studies Genetic Heterogeneity Humans IAP‐retrotransposon Liability methylation Mice Mice, Transgenic Morphology Palate - embryology Palate - pathology Phenotype Phenotypes Phenotypic variations Retroelements - genetics Wnt Proteins - genetics Wnt9b
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