mRNA structural dynamics shape Argonaute-target interactions

Small interfering RNAs (siRNAs) promote RNA degradation in a variety of processes and have important clinical applications. siRNAs direct cleavage of target RNAs by guiding Argonaute2 (AGO2) to its target site. Target site accessibility is critical for AGO2-target interactions, but how target site a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature structural & molecular biology 2020-09, Vol.27 (9), p.790-801
Hauptverfasser:	Ruijtenberg, Suzan, Sonneveld, Stijn, Cui, Tao Ju, Logister, Ive, de Steenwinkel, Dion, Xiao, Yao, MacRae, Ian J., Joo, Chirlmin, Tanenbaum, Marvin E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/337/384/2053 631/57 631/80 Accessibility Argonaute 2 protein Argonaute Proteins - metabolism Binding proteins Binding sites Biochemistry Biological Microscopy Biomedical and Life Sciences Cell Line Cleavage Constraining HEK293 Cells Humans In vivo methods and tests Life Sciences Masking Membrane Biology Messenger RNA Microscopy Molecular biology mRNA Nucleic Acid Conformation Protein interaction Protein research Protein Structure Protein-protein interactions Proteins Rate constants Ribosomes Ribosomes - metabolism RNA Cleavage RNA Folding RNA, Messenger - chemistry RNA, Messenger - metabolism Shape recognition siRNA Structure Target masking Target recognition
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!