SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms underpinning virus‐associated inflammation is required to develop effective therapeutics. Here, we discover that SARS‐CoV‐2 replicates rapidly in lu...

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Veröffentlicht in:	The EMBO journal 2021-08, Vol.40 (15), p.e107826-n/a
Hauptverfasser:	Thorne, Lucy G, Reuschl, Ann‐Kathrin, Zuliani‐Alvarez, Lorena, Whelan, Matthew V X, Turner, Jane, Noursadeghi, Mahdad, Jolly, Clare, Towers, Greg J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell activation Cell Line Cellular manufacture COVID-19 COVID-19 - genetics COVID-19 - immunology COVID-19 - virology Cytokines Cytokines - genetics Cytokines - immunology DEAD Box Protein 58 - immunology EMBO19 EMBO23 epithelial Epithelial cells Epithelial Cells - immunology Epithelial Cells - virology Epithelium Host-Pathogen Interactions Humans Immune response Immune system Immunity, Innate Immunomodulation Immunomodulators Infections Inflammation Inflammation - genetics Inflammation - immunology Inflammation - virology Innate immunity Interferon-Induced Helicase, IFIH1 - immunology Janus Kinases - immunology Lung - cytology Lung - immunology Lung - virology Lungs macrophage Macrophage Activation Macrophages Macrophages - immunology NF-kappa B - immunology Receptors, Immunologic - immunology Respiratory Mucosa - cytology Respiratory Mucosa - immunology Respiratory Mucosa - virology Ribonucleic acid RNA RNA sensing RNA, Viral - immunology Robustness SARS-CoV-2 - genetics SARS-CoV-2 - physiology SARS‐CoV‐2 Sensors Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signal transduction STAT Transcription Factors - immunology Stimuli Viral diseases Virus Replication
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