Neuronal loss and microgliosis are restricted to the core of Aβ deposits in mouse models of Alzheimer's disease

Amyloid‐β (Aβ) deposits, pathologic tau, and neurodegeneration are major pathological hallmarks of Alzheimer's disease (AD). The relationship between neuronal loss and Aβ deposits is one of the fundamental questions in the pathogenesis of AD. However, this relationship is controversial. One mai...

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Veröffentlicht in:	Aging cell 2021-06, Vol.20 (6), p.e13380-n/a
Hauptverfasser:	Zhang, Jing, Wu, Na, Wang, Shubo, Yao, Zitong, Xiao, Fuchuan, Lu, Jing, Chen, Baian
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - genetics Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Animal models Animals Antibodies axon loss Axons Aβ deposits Brain Cell body Cognitive ability Deposits Disease Models, Animal Humans Inflammation Localization Male Medical research Mice Microglia Microglia - metabolism Mutation Myelin myelin sheath loss Neurodegeneration Neurodegenerative diseases neuron loss Neurons Neurons - metabolism Original Original Paper Rodents Tau protein Toxicity
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