Targeting a neoantigen derived from a common TP53 mutation

(tumor protein p53) is the most commonly mutated cancer driver gene, but drugs that target mutant tumor suppressor genes, such as , are not yet available. Here, we describe the identification of an antibody highly specific to the most common mutation (R175H, in which arginine at position 175 is repl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2021-03, Vol.371 (6533)
Hauptverfasser:	Hsiue, Emily Han-Chung, Wright, Katharine M, Douglass, Jacqueline, Hwang, Michael S, Mog, Brian J, Pearlman, Alexander H, Paul, Suman, DiNapoli, Sarah R, Konig, Maximilian F, Wang, Qing, Schaefer, Annika, Miller, Michelle S, Skora, Andrew D, Azurmendi, P Aitana, Murphy, Michael B, Liu, Qiang, Watson, Evangeline, Li, Yana, Pardoll, Drew M, Bettegowda, Chetan, Papadopoulos, Nickolas, Kinzler, Kenneth W, Vogelstein, Bert, Gabelli, Sandra B, Zhou, Shibin
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Alleles Amino acids Animals Antibodies Antibodies, Bispecific - chemistry Antibodies, Bispecific - immunology Antibodies, Bispecific - therapeutic use Antibodies, Neoplasm - chemistry Antibodies, Neoplasm - immunology Antibodies, Neoplasm - therapeutic use Antigens Antigens, Neoplasm - immunology Arginine Arginine - genetics Bispecific antibodies Cages Cancer Cancer therapies CD3 antigen Cell surface Chains Chlorocebus aethiops COS Cells Cytokines Deactivation Density Drug development Drugs Epidermal growth factor Epidermal growth factor receptors Female Fragments Genes Growth factors HEK293 Cells Histidine Histidine - genetics Histocompatibility antigen HLA HLA-A2 Antigen - chemistry HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Immune system Immunization, Passive Jurkat Cells Leukocytes Lymphocyte Activation Lymphocytes Lymphocytes T Mass spectrometry Mice Mice, Inbred NOD Mutants Mutation Narcotics Neoantigens Neoplasms - therapy Pathogenesis Peptides Phages Proteasomes Proteins Receptors Scientific Concepts T cell receptors T-Lymphocytes - immunology Tumor cells Tumor suppressor genes Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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