Severe microcephaly, intellectual disability and epilepsy: the ravages of congenital syphilis
According to the recent global and regional estimates of maternal and congenital syphilis, the global maternal syphilis prevalence rate was 0.69% and the estimated congenital syphilis case rate was 473 cases per lakh live births in 2016.1 The highest rates are in Africa, followed by the regions of A...
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| description | According to the recent global and regional estimates of maternal and congenital syphilis, the global maternal syphilis prevalence rate was 0.69% and the estimated congenital syphilis case rate was 473 cases per lakh live births in 2016.1 The highest rates are in Africa, followed by the regions of America and the eastern Mediterranean region.1 In comparison, the South-East Asian region showed a lower maternal syphilis prevalence rate (0.21%) and a lower estimated congenital syphilis case rate (145 cases per lakh live births).1 The exact incidence of congenital syphilis in India is not known, the estimated incidence was 0.6 cases per 1000 live births in 2012.2 Despite the global and regional differences, this preventable cause of neurodisability is not completely eliminated and often escapes a timely diagnosis or treatment. In a Brazilian study of neonates with congenital syphilis and follow-up from birth up to 5 years, congenital syphilis was associated with still births, preterm delivery ( |
| doi_str_mv | 10.1136/bcr-2021-244203 |
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In a Brazilian study of neonates with congenital syphilis and follow-up from birth up to 5 years, congenital syphilis was associated with still births, preterm delivery (<34 weeks), low birth weight and small for gestational age.5 Only one-third of the patients could be followed up between 8 and 60 months, and the majority showed good outcomes when treated adequately; nearly 1/10 of the cases showed sequelae.5 Thus, congenital syphilis remains an impacting disease throughout the life of a newborn. [...]paediatricians should consider congenital syphilis in any infant with suspicious clinical findings, despite maternal serological status.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2021-244203</identifier><identifier>PMID: 34130983</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Births ; Brain ; Brain research ; Case reports ; Childbirth & labor ; Congenital diseases ; Epilepsy - complications ; Glucose ; Humans ; Images In ; Intellectual disabilities ; Intellectual Disability - complications ; Microcephaly ; Nervous system ; Neuroimaging ; Pediatrics ; Syphilis ; Syphilis, Congenital - complications ; Syphilis, Congenital - diagnosis ; Syphilis, Congenital - drug therapy</subject><ispartof>BMJ case reports, 2021-06, Vol.14 (6), p.e244203</ispartof><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2021 BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2021. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-b410t-73c41dcce9d339981b1a6e1619bb36a38ac9e5b19ed1d1933ff1bc1c44c49ca03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207996/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207996/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34130983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saini, Arushi Gahlot</creatorcontrib><creatorcontrib>Kamila, Gautam</creatorcontrib><creatorcontrib>Vyas, Sameer</creatorcontrib><title>Severe microcephaly, intellectual disability and epilepsy: the ravages of congenital syphilis</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>According to the recent global and regional estimates of maternal and congenital syphilis, the global maternal syphilis prevalence rate was 0.69% and the estimated congenital syphilis case rate was 473 cases per lakh live births in 2016.1 The highest rates are in Africa, followed by the regions of America and the eastern Mediterranean region.1 In comparison, the South-East Asian region showed a lower maternal syphilis prevalence rate (0.21%) and a lower estimated congenital syphilis case rate (145 cases per lakh live births).1 The exact incidence of congenital syphilis in India is not known, the estimated incidence was 0.6 cases per 1000 live births in 2012.2 Despite the global and regional differences, this preventable cause of neurodisability is not completely eliminated and often escapes a timely diagnosis or treatment. In a Brazilian study of neonates with congenital syphilis and follow-up from birth up to 5 years, congenital syphilis was associated with still births, preterm delivery (<34 weeks), low birth weight and small for gestational age.5 Only one-third of the patients could be followed up between 8 and 60 months, and the majority showed good outcomes when treated adequately; nearly 1/10 of the cases showed sequelae.5 Thus, congenital syphilis remains an impacting disease throughout the life of a newborn. [...]paediatricians should consider congenital syphilis in any infant with suspicious clinical findings, despite maternal serological status.</description><subject>Births</subject><subject>Brain</subject><subject>Brain research</subject><subject>Case reports</subject><subject>Childbirth & labor</subject><subject>Congenital diseases</subject><subject>Epilepsy - complications</subject><subject>Glucose</subject><subject>Humans</subject><subject>Images In</subject><subject>Intellectual disabilities</subject><subject>Intellectual Disability - complications</subject><subject>Microcephaly</subject><subject>Nervous system</subject><subject>Neuroimaging</subject><subject>Pediatrics</subject><subject>Syphilis</subject><subject>Syphilis, Congenital - complications</subject><subject>Syphilis, Congenital - diagnosis</subject><subject>Syphilis, Congenital - drug therapy</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc1r3DAQxUVoSUKac25BkEspcaOxZFvqIVBC0xYCPaSFXoqQ5PGuFn9Vshf831ebTULaS3UZwfzeY2YeIWfA3gPw8sq6kOUshywXImf8gBxDVVRZpdjPVy_-R-Q0xg1Lj4OQgh-SIy6AMyX5Mfl1j1sMSDvvwuBwXJt2uaS-n7Bt0U2zaWnto7G-9dNCTV9THH2LY1w-0GmNNJitWWGkQ0Pd0K-w91OSxGVcJ0V8Q143po14-lhPyI_bT99vvmR33z5_vfl4l1kBbMoq7gTUzqGqOVdKggVTIpSgrOWl4dI4hYUFhTXUoDhvGrAOnBBOKGcYPyHXe99xth3WDvspmFaPwXcmLHowXv_d6f1ar4atljmrlCqTwdtHgzD8njFOuvPRpRuYHoc56rwQUEnJCpnQi3_QzTCHPq33QOUgi3I30dWeSmeNMWDzPAwwvUtPp_T0Lj29Ty8pzl_u8Mw_ZZWAd3vAdpv_uv0BgMOkqw</recordid><startdate>20210615</startdate><enddate>20210615</enddate><creator>Saini, Arushi Gahlot</creator><creator>Kamila, Gautam</creator><creator>Vyas, Sameer</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210615</creationdate><title>Severe microcephaly, intellectual disability and epilepsy: the ravages of congenital syphilis</title><author>Saini, Arushi Gahlot ; Kamila, Gautam ; Vyas, Sameer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b410t-73c41dcce9d339981b1a6e1619bb36a38ac9e5b19ed1d1933ff1bc1c44c49ca03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Births</topic><topic>Brain</topic><topic>Brain research</topic><topic>Case reports</topic><topic>Childbirth & labor</topic><topic>Congenital diseases</topic><topic>Epilepsy - complications</topic><topic>Glucose</topic><topic>Humans</topic><topic>Images In</topic><topic>Intellectual disabilities</topic><topic>Intellectual Disability - complications</topic><topic>Microcephaly</topic><topic>Nervous system</topic><topic>Neuroimaging</topic><topic>Pediatrics</topic><topic>Syphilis</topic><topic>Syphilis, Congenital - complications</topic><topic>Syphilis, Congenital - diagnosis</topic><topic>Syphilis, Congenital - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saini, Arushi Gahlot</creatorcontrib><creatorcontrib>Kamila, Gautam</creatorcontrib><creatorcontrib>Vyas, Sameer</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saini, Arushi Gahlot</au><au>Kamila, Gautam</au><au>Vyas, Sameer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe microcephaly, intellectual disability and epilepsy: the ravages of congenital syphilis</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2021-06-15</date><risdate>2021</risdate><volume>14</volume><issue>6</issue><spage>e244203</spage><pages>e244203-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>According to the recent global and regional estimates of maternal and congenital syphilis, the global maternal syphilis prevalence rate was 0.69% and the estimated congenital syphilis case rate was 473 cases per lakh live births in 2016.1 The highest rates are in Africa, followed by the regions of America and the eastern Mediterranean region.1 In comparison, the South-East Asian region showed a lower maternal syphilis prevalence rate (0.21%) and a lower estimated congenital syphilis case rate (145 cases per lakh live births).1 The exact incidence of congenital syphilis in India is not known, the estimated incidence was 0.6 cases per 1000 live births in 2012.2 Despite the global and regional differences, this preventable cause of neurodisability is not completely eliminated and often escapes a timely diagnosis or treatment. In a Brazilian study of neonates with congenital syphilis and follow-up from birth up to 5 years, congenital syphilis was associated with still births, preterm delivery (<34 weeks), low birth weight and small for gestational age.5 Only one-third of the patients could be followed up between 8 and 60 months, and the majority showed good outcomes when treated adequately; nearly 1/10 of the cases showed sequelae.5 Thus, congenital syphilis remains an impacting disease throughout the life of a newborn. [...]paediatricians should consider congenital syphilis in any infant with suspicious clinical findings, despite maternal serological status.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>34130983</pmid><doi>10.1136/bcr-2021-244203</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Births Brain Brain research Case reports Childbirth & labor Congenital diseases Epilepsy - complications Glucose Humans Images In Intellectual disabilities Intellectual Disability - complications Microcephaly Nervous system Neuroimaging Pediatrics Syphilis Syphilis, Congenital - complications Syphilis, Congenital - diagnosis Syphilis, Congenital - drug therapy |
| title | Severe microcephaly, intellectual disability and epilepsy: the ravages of congenital syphilis |
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