Persistence of Zika virus RNA in the epididymis of the murine male reproductive tract

Zika virus (ZIKV) can infect developing fetuses in utero and cause severe congenital defects independent of route of maternal infection. Infected men can shed ZIKV RNA in semen for over six months. Whether prolonged viral RNA shedding in semen indicates a persistent infection in the male reproductiv...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2021-08, Vol.560, p.43-53
Hauptverfasser:	Vogt, Megan B., Frere, Francesca, Hawks, Seth A., Perez, Claudia E., Coutermarsh-Ott, Sheryl, Duggal, Nisha K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Chlorocebus aethiops chronic diseases cyclophosphamide Cyclophosphamide - pharmacology Epididymis Epididymis - virology Immune Tolerance - immunology Immunocompromised Host - immunology immunosuppression Immunosuppressive Agents - pharmacology Male Male reproductive tract males Mice Mice, Inbred C57BL Mouse model Persistent Infection - virology public health Recrudescence Recurrence RNA RNA, Viral - genetics RNA, Viral - isolation & purification Semen Semen - virology Sexual transmission Sexually Transmitted Diseases, Viral - transmission Vero Cells virology Virus Shedding - genetics viruses Zika virus Zika Virus - genetics Zika Virus - isolation & purification Zika Virus Infection - transmission
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