Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites
Abstract Context Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism. Objective To assess statin utilization in LT4-treated patients through an observational drug utilization study. Methods Three sites were involved: (1) 10 723 outpatient...
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| Veröffentlicht in: | Journal of the Endocrine Society 2021-07, Vol.5 (7), p.bvab038-bvab038 |
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| creator | Idrees, Thaer Prieto, Wesley H Casula, Sabina Ajith, Aswathy Ettleson, Matthew Narchi, Flavia A Andreotti Russo, Pedro S T Fernandes, Fernando Johnson, Julie Mayampurath, Anoop Maciel, Rui M B Bianco, Antonio C |
| description | Abstract
Context
Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism.
Objective
To assess statin utilization in LT4-treated patients through an observational drug utilization study.
Methods
Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil.
Results
On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were |
| doi_str_mv | 10.1210/jendso/bvab038 |
| format | Article |
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Context
Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism.
Objective
To assess statin utilization in LT4-treated patients through an observational drug utilization study.
Methods
Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil.
Results
On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were <.0001.
Conclusion
Prescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies.</description><identifier>ISSN: 2472-1972</identifier><identifier>EISSN: 2472-1972</identifier><identifier>DOI: 10.1210/jendso/bvab038</identifier><identifier>PMID: 34141994</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Clinical ; Evidence-based medicine ; Hypothyroidism ; Medical research ; Medicine, Experimental ; Patient compliance ; Statins ; Thyrotropin ; Warehouse stores</subject><ispartof>Journal of the Endocrine Society, 2021-07, Vol.5 (7), p.bvab038-bvab038</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-2e980cefa47df81ba5869a166fdbfc1e7b219f7f9667e427bf069dd039d0539f3</citedby><cites>FETCH-LOGICAL-c491t-2e980cefa47df81ba5869a166fdbfc1e7b219f7f9667e427bf069dd039d0539f3</cites><orcidid>0000-0001-7737-6813</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204793/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8204793/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34141994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Idrees, Thaer</creatorcontrib><creatorcontrib>Prieto, Wesley H</creatorcontrib><creatorcontrib>Casula, Sabina</creatorcontrib><creatorcontrib>Ajith, Aswathy</creatorcontrib><creatorcontrib>Ettleson, Matthew</creatorcontrib><creatorcontrib>Narchi, Flavia A Andreotti</creatorcontrib><creatorcontrib>Russo, Pedro S T</creatorcontrib><creatorcontrib>Fernandes, Fernando</creatorcontrib><creatorcontrib>Johnson, Julie</creatorcontrib><creatorcontrib>Mayampurath, Anoop</creatorcontrib><creatorcontrib>Maciel, Rui M B</creatorcontrib><creatorcontrib>Bianco, Antonio C</creatorcontrib><title>Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites</title><title>Journal of the Endocrine Society</title><addtitle>J Endocr Soc</addtitle><description>Abstract
Context
Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism.
Objective
To assess statin utilization in LT4-treated patients through an observational drug utilization study.
Methods
Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil.
Results
On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were <.0001.
Conclusion
Prescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies.</description><subject>Clinical</subject><subject>Evidence-based medicine</subject><subject>Hypothyroidism</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Patient compliance</subject><subject>Statins</subject><subject>Thyrotropin</subject><subject>Warehouse stores</subject><issn>2472-1972</issn><issn>2472-1972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkU1rGzEQhkVpaUKaa49F0EtzcKKvXa16KJj0EwwpJD4L7WpkK92VXGnX1P31VWI3pBCodJBm9MzLaF6EXlNyThklF7cQbI4X7da0hDfP0DETks2okuz5o_sROs35lhBCFRdKiJfoiAsqqFLiGK2XGXB0-Ho0ow8Zz4cYVvh7CSCMGd-YH77EC9jGcb1L8ZcP8B6bgK_aDGlbsBhMjz-maYWXo-_97_tUkZvsDs-7FHPG136E_Aq9cKbPcHo4T9Dy86eby6-zxdWXb5fzxawTio4zBqohHTgjpHUNbU3V1MrQuna2dR0F2TKqnHSqriUIJltHamUt4cqSiivHT9CHve5magewXflGMr3eJD-YtNPReP3vS_BrvYpb3TAipOJF4N1BIMWfE-RRDz530PcmQJyyZpXgoixeFfTtHl2ZHrQPLhbF7g7Xcymr0noZdKHOn6DKtjD4LgZwvuSfKrgfXwL30D0l-s54vTdeH4wvBW8e__kB_2tzAc72QJw2_xP7A04iuxA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Idrees, Thaer</creator><creator>Prieto, Wesley H</creator><creator>Casula, Sabina</creator><creator>Ajith, Aswathy</creator><creator>Ettleson, Matthew</creator><creator>Narchi, Flavia A Andreotti</creator><creator>Russo, Pedro S T</creator><creator>Fernandes, Fernando</creator><creator>Johnson, Julie</creator><creator>Mayampurath, Anoop</creator><creator>Maciel, Rui M B</creator><creator>Bianco, Antonio C</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7737-6813</orcidid></search><sort><creationdate>20210701</creationdate><title>Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites</title><author>Idrees, Thaer ; Prieto, Wesley H ; Casula, Sabina ; Ajith, Aswathy ; Ettleson, Matthew ; Narchi, Flavia A Andreotti ; Russo, Pedro S T ; Fernandes, Fernando ; Johnson, Julie ; Mayampurath, Anoop ; Maciel, Rui M B ; Bianco, Antonio C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-2e980cefa47df81ba5869a166fdbfc1e7b219f7f9667e427bf069dd039d0539f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Clinical</topic><topic>Evidence-based medicine</topic><topic>Hypothyroidism</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Patient compliance</topic><topic>Statins</topic><topic>Thyrotropin</topic><topic>Warehouse stores</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idrees, Thaer</creatorcontrib><creatorcontrib>Prieto, Wesley H</creatorcontrib><creatorcontrib>Casula, Sabina</creatorcontrib><creatorcontrib>Ajith, Aswathy</creatorcontrib><creatorcontrib>Ettleson, Matthew</creatorcontrib><creatorcontrib>Narchi, Flavia A Andreotti</creatorcontrib><creatorcontrib>Russo, Pedro S T</creatorcontrib><creatorcontrib>Fernandes, Fernando</creatorcontrib><creatorcontrib>Johnson, Julie</creatorcontrib><creatorcontrib>Mayampurath, Anoop</creatorcontrib><creatorcontrib>Maciel, Rui M B</creatorcontrib><creatorcontrib>Bianco, Antonio C</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the Endocrine Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idrees, Thaer</au><au>Prieto, Wesley H</au><au>Casula, Sabina</au><au>Ajith, Aswathy</au><au>Ettleson, Matthew</au><au>Narchi, Flavia A Andreotti</au><au>Russo, Pedro S T</au><au>Fernandes, Fernando</au><au>Johnson, Julie</au><au>Mayampurath, Anoop</au><au>Maciel, Rui M B</au><au>Bianco, Antonio C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites</atitle><jtitle>Journal of the Endocrine Society</jtitle><addtitle>J Endocr Soc</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>5</volume><issue>7</issue><spage>bvab038</spage><epage>bvab038</epage><pages>bvab038-bvab038</pages><issn>2472-1972</issn><eissn>2472-1972</eissn><abstract>Abstract
Context
Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism.
Objective
To assess statin utilization in LT4-treated patients through an observational drug utilization study.
Methods
Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil.
Results
On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were <.0001.
Conclusion
Prescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>34141994</pmid><doi>10.1210/jendso/bvab038</doi><orcidid>https://orcid.org/0000-0001-7737-6813</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Clinical Evidence-based medicine Hypothyroidism Medical research Medicine, Experimental Patient compliance Statins Thyrotropin Warehouse stores |
| title | Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites |
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