In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs
The intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (H 2 SO 4 + HNO 3 ). 5-flurouracil was load...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2021-06, Vol.32 (6), p.71-71, Article 71 |
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| creator | Kamble, Rutuja V. Bhinge, Somnath D. Mohite, Shrinivas K. Randive, Dheeraj S. Bhutkar, Mangesh A. |
| description | The intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (H
2
SO
4
+ HNO
3
). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Also the prepared f-CNTs, 5-flurouracil loaded CNTs were distinguished by using SEM, TGA, DSC, X-ray diffraction, Raman and FTIR spectroscopy. MCF-7 and COLO320DM cells were treated with selected concentrations of 5-FU loaded f-MWCNTs and f-SWCNTs to estimate the cytotoxic activity. It was observed that 5-FU loaded f-SWCNTs showed good activity against selected cell lines than others. Moreover, apoptosis percentage was reported to be 84.46 ± 4.3515 and 92.78 ± 2.6549 for 5-FU loaded f-SWCNTs against MCF-7 and COLO320DM cells respectively. It is evident from the results that the prepared drug loaded CNTs have comparable antitumor activity in cancer cell lines. |
| doi_str_mv | 10.1007/s10856-021-06540-8 |
| format | Article |
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2
SO
4
+ HNO
3
). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Also the prepared f-CNTs, 5-flurouracil loaded CNTs were distinguished by using SEM, TGA, DSC, X-ray diffraction, Raman and FTIR spectroscopy. MCF-7 and COLO320DM cells were treated with selected concentrations of 5-FU loaded f-MWCNTs and f-SWCNTs to estimate the cytotoxic activity. It was observed that 5-FU loaded f-SWCNTs showed good activity against selected cell lines than others. Moreover, apoptosis percentage was reported to be 84.46 ± 4.3515 and 92.78 ± 2.6549 for 5-FU loaded f-SWCNTs against MCF-7 and COLO320DM cells respectively. It is evident from the results that the prepared drug loaded CNTs have comparable antitumor activity in cancer cell lines.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-021-06540-8</identifier><identifier>PMID: 34125294</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>5-Fluorouracil ; Anticancer properties ; Antitumor activity ; Apoptosis ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Calorimetry, Differential Scanning ; Cell Line, Tumor ; Ceramics ; Chemistry and Materials Science ; Chromatin - chemistry ; Composites ; Cytotoxicity ; Delivery Systems ; Drug Delivery Systems ; Drug Liberation ; Fluorouracil - pharmacology ; Functional groups ; Glass ; Humans ; In Vitro Techniques ; Materials Science ; MCF-7 Cells ; Microscopy, Electron, Scanning ; Nanotubes, Carbon - chemistry ; Natural Materials ; Nitric Acid - chemistry ; Polymer Sciences ; Regenerative Medicine/Tissue Engineering ; Spectroscopy, Fourier Transform Infrared ; Spectrum Analysis, Raman ; Sulfuric acid ; Sulfuric Acids - chemistry ; Surfaces and Interfaces ; Thermogravimetry ; Thin Films ; Tumor cell lines ; X-Ray Diffraction</subject><ispartof>Journal of materials science. Materials in medicine, 2021-06, Vol.32 (6), p.71-71, Article 71</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-590bd7d37d8944b19d0a5a0a3108be75b42ffee2b274ab2ab5cf50cd1e3cf3113</citedby><cites>FETCH-LOGICAL-c474t-590bd7d37d8944b19d0a5a0a3108be75b42ffee2b274ab2ab5cf50cd1e3cf3113</cites><orcidid>0000-0002-5959-5833</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-021-06540-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://doi.org/10.1007/s10856-021-06540-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,860,881,27903,27904,41099,41467,42168,42536,51297,51554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34125294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamble, Rutuja V.</creatorcontrib><creatorcontrib>Bhinge, Somnath D.</creatorcontrib><creatorcontrib>Mohite, Shrinivas K.</creatorcontrib><creatorcontrib>Randive, Dheeraj S.</creatorcontrib><creatorcontrib>Bhutkar, Mangesh A.</creatorcontrib><title>In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>The intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (H
2
SO
4
+ HNO
3
). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Also the prepared f-CNTs, 5-flurouracil loaded CNTs were distinguished by using SEM, TGA, DSC, X-ray diffraction, Raman and FTIR spectroscopy. MCF-7 and COLO320DM cells were treated with selected concentrations of 5-FU loaded f-MWCNTs and f-SWCNTs to estimate the cytotoxic activity. It was observed that 5-FU loaded f-SWCNTs showed good activity against selected cell lines than others. Moreover, apoptosis percentage was reported to be 84.46 ± 4.3515 and 92.78 ± 2.6549 for 5-FU loaded f-SWCNTs against MCF-7 and COLO320DM cells respectively. It is evident from the results that the prepared drug loaded CNTs have comparable antitumor activity in cancer cell lines.</description><subject>5-Fluorouracil</subject><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Calorimetry, Differential Scanning</subject><subject>Cell Line, Tumor</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Chromatin - chemistry</subject><subject>Composites</subject><subject>Cytotoxicity</subject><subject>Delivery Systems</subject><subject>Drug Delivery Systems</subject><subject>Drug Liberation</subject><subject>Fluorouracil - pharmacology</subject><subject>Functional groups</subject><subject>Glass</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Materials Science</subject><subject>MCF-7 Cells</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nanotubes, Carbon - chemistry</subject><subject>Natural Materials</subject><subject>Nitric Acid - chemistry</subject><subject>Polymer Sciences</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Spectrum Analysis, Raman</subject><subject>Sulfuric acid</subject><subject>Sulfuric Acids - chemistry</subject><subject>Surfaces and Interfaces</subject><subject>Thermogravimetry</subject><subject>Thin Films</subject><subject>Tumor cell lines</subject><subject>X-Ray 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vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs</title><author>Kamble, Rutuja V. ; Bhinge, Somnath D. ; Mohite, Shrinivas K. ; Randive, Dheeraj S. ; Bhutkar, Mangesh A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-590bd7d37d8944b19d0a5a0a3108be75b42ffee2b274ab2ab5cf50cd1e3cf3113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>5-Fluorouracil</topic><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Biomaterials</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Calorimetry, Differential Scanning</topic><topic>Cell Line, Tumor</topic><topic>Ceramics</topic><topic>Chemistry and Materials Science</topic><topic>Chromatin - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamble, Rutuja V.</au><au>Bhinge, Somnath D.</au><au>Mohite, Shrinivas K.</au><au>Randive, Dheeraj S.</au><au>Bhutkar, Mangesh A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>32</volume><issue>6</issue><spage>71</spage><epage>71</epage><pages>71-71</pages><artnum>71</artnum><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>The intention of the present work was to synthesize the f-MWCNT and f-SWCNT terminated with proper functional group, loading of 5-Flurouracil and to perform cytotoxic activity. Functionalization of MWCNTs and SWCNTs was achieved through the acid treatment (H
2
SO
4
+ HNO
3
). 5-flurouracil was loaded into the prepared functionalized CNTs, thereafter; in vitro drug loading capacity and % drug release were calculated. Also the prepared f-CNTs, 5-flurouracil loaded CNTs were distinguished by using SEM, TGA, DSC, X-ray diffraction, Raman and FTIR spectroscopy. MCF-7 and COLO320DM cells were treated with selected concentrations of 5-FU loaded f-MWCNTs and f-SWCNTs to estimate the cytotoxic activity. It was observed that 5-FU loaded f-SWCNTs showed good activity against selected cell lines than others. Moreover, apoptosis percentage was reported to be 84.46 ± 4.3515 and 92.78 ± 2.6549 for 5-FU loaded f-SWCNTs against MCF-7 and COLO320DM cells respectively. It is evident from the results that the prepared drug loaded CNTs have comparable antitumor activity in cancer cell lines.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34125294</pmid><doi>10.1007/s10856-021-06540-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-5959-5833</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2021-06, Vol.32 (6), p.71-71, Article 71 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; SpringerLink Journals - AutoHoldings |
| subjects | 5-Fluorouracil Anticancer properties Antitumor activity Apoptosis Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Calorimetry, Differential Scanning Cell Line, Tumor Ceramics Chemistry and Materials Science Chromatin - chemistry Composites Cytotoxicity Delivery Systems Drug Delivery Systems Drug Liberation Fluorouracil - pharmacology Functional groups Glass Humans In Vitro Techniques Materials Science MCF-7 Cells Microscopy, Electron, Scanning Nanotubes, Carbon - chemistry Natural Materials Nitric Acid - chemistry Polymer Sciences Regenerative Medicine/Tissue Engineering Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Sulfuric acid Sulfuric Acids - chemistry Surfaces and Interfaces Thermogravimetry Thin Films Tumor cell lines X-Ray Diffraction |
| title | In vitro targeting and selective killing of mcf-7 and colo320dm cells by 5-fluorouracil anchored to carboxylated SWCNTs and MWCNTs |
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