The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieve a durable remission. Sirtuin 5 (SIRT5) is a memb...

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Veröffentlicht in:	The Journal of clinical investigation 2021-06, Vol.131 (12), p.1-18
Hauptverfasser:	Giblin, William, Bringman-Rodenbarger, Lauren, Guo, Angela H, Kumar, Surinder, Monovich, Alexander C, Mostafa, Ahmed M, Skinner, Mary E, Azar, Michelle, Mady, Ahmed Sa, Chung, Carolina H, Kadambi, Namrata, Melong, Keith-Allen, Lee, Ho-Joon, Zhang, Li, Sajjakulnukit, Peter, Trefely, Sophie, Varner, Erika L, Iyer, Sowmya, Wang, Min, Wilmott, James S, Soyer, H Peter, Sturm, Richard A, Pritchard, Antonia L, Andea, Aleodor A, Scolyer, Richard A, Stark, Mitchell S, Scott, David A, Fullen, Douglas R, Bosenberg, Marcus W, Chandrasekaran, Sriram, Nikolovska-Coleska, Zaneta, Verhaegen, Monique E, Snyder, Nathaniel W, Rivera, Miguel N, Osterman, Andrei L, Lyssiotis, Costas A, Lombard, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Addictions Animals Apoptosis Biomedical research Breast cancer c-Myc protein Cancer Chromatin Chromatin - enzymology Chromatin - genetics Chromosomes Dehydrogenases Development and progression DNA methylation Gene expression Genetic aspects Genotypes Health aspects Histones Immune checkpoint Lung cancer Medical prognosis Melanoma Melanoma - enzymology Melanoma - genetics Melanoma - pathology Melanoma, Cutaneous Malignant Melanoma, Experimental - enzymology Melanoma, Experimental - genetics Melanoma, Experimental - pathology Metabolism Metabolites Metastases Metastasis Mice Microphthalmia-associated transcription factor Mutation Myc protein Oncology, Experimental Phenotypes Protein turnover Proto-Oncogene Mas Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism PTEN protein Remission Remission (Medicine) Senescence Sirtuins - genetics Sirtuins - metabolism Skin cancer Skin Neoplasms - enzymology Skin Neoplasms - genetics Skin Neoplasms - pathology Transcription factors Transferases Tumorigenesis Xenografts
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