G9a Regulates Cell Sensitivity to Radiotherapy via Histone H3 Lysine 9 Trimethylation and CCDC8 in Lung Cancer

To investigate the role and underlying mechanism of G9a and CCDC8 in lung cancer radioresistance. Western blotting assays were used for G9a, CCDC8, H3K9me3 expression detection. MTT assays and clone formation assays were used for measuring cell proliferation activities. Flow cytometry assays were us...

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Veröffentlicht in:	OncoTargets and therapy 2021-01, Vol.14, p.3721-3728
Hauptverfasser:	Li, Yunfen, Chen, Zhengting, Cao, Ke, Zhang, Lan, Ma, Yuhui, Yu, Shuhui, Jin, Hanyu, Liu, Xiaoling, Li, Wenhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Cancer therapies Cell growth Cell proliferation Chromatin Cloning DNA methylation Epigenetics Flow cytometry Genes Histone H3 Histones Immunoprecipitation Lung cancer Lysine Original Research Proteins Quantitative analysis Radiation therapy Radioresistance Radiosensitivity Radiotherapy Statistical analysis Tumor suppressor genes Western blotting
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