Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease
Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the interest of researchers since studies have shown that its effects are not restricted to bone metabolism. Thus, the present review summarizes the most recent findings and discusses the usefulness of prescribing vitamin D...
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| Veröffentlicht in: | Jornal vascular brasileiro 2020-07, Vol.19, p.e20190150-e20190150 |
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| container_title | Jornal vascular brasileiro |
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| creator | Cardoso, Felipe Esdras Lucas Dos Santos, Leandro da Cruz Melgaço Tenório, Adirlene Pontes de Oliveira Lopes, Matheus Rodrigues Barbosa, Romero Henrique de Almeida |
| description | Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the
interest of researchers since studies have shown that its effects are not restricted
to bone metabolism. Thus, the present review summarizes the most recent findings and
discusses the usefulness of prescribing vitamin D and its analogues for treatment and
prevention of cardiovascular disorders and endothelial dysfunction. The paper
constitutes a narrative review of the literature, selecting articles published from
2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial
effects on endothelial function, but these results are controversial, since research
with larger samples and of longer duration found no reduction in morbidity and
mortality or cardiovascular risk factors after use of these substances. Given the
current state of the art, there is no clear scientific basis for supplementation with
vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular
disease. |
| doi_str_mv | 10.1590/1677-5449.190150 |
| format | Article |
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interest of researchers since studies have shown that its effects are not restricted
to bone metabolism. Thus, the present review summarizes the most recent findings and
discusses the usefulness of prescribing vitamin D and its analogues for treatment and
prevention of cardiovascular disorders and endothelial dysfunction. The paper
constitutes a narrative review of the literature, selecting articles published from
2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial
effects on endothelial function, but these results are controversial, since research
with larger samples and of longer duration found no reduction in morbidity and
mortality or cardiovascular risk factors after use of these substances. Given the
current state of the art, there is no clear scientific basis for supplementation with
vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular
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interest of researchers since studies have shown that its effects are not restricted
to bone metabolism. Thus, the present review summarizes the most recent findings and
discusses the usefulness of prescribing vitamin D and its analogues for treatment and
prevention of cardiovascular disorders and endothelial dysfunction. The paper
constitutes a narrative review of the literature, selecting articles published from
2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial
effects on endothelial function, but these results are controversial, since research
with larger samples and of longer duration found no reduction in morbidity and
mortality or cardiovascular risk factors after use of these substances. Given the
current state of the art, there is no clear scientific basis for supplementation with
vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular
disease.</description><subject>Review</subject><issn>1677-5449</issn><issn>1677-7301</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVjjtPAzEQhC0EghDoKV3SJNj38rlBQuEpRaIA6tPGXidGvvNh-4Ly77lAGpqd1Y7mmyXkirM5LyW74ZUQs7Io5JxLxkt2RCa_J5EzfnzY9_YZOY_xk7GiFJk8JWd5wUXNRD4h4W3oe4ctdgmS9R39tmlDtzZBazt6T6HT1KY4Kji_jtT4QFNASPsE9YZip33aoLPgqN5FM3Tql7MPKgja-i1ENTgIVNuIEPGCnBhwES8POiUfjw_vi-fZ8vXpZXG3nPW8rNNMoEIpTSGFhtU4lcoxy0wNHDVgXpmV4qLiRpUGstrUVQEV1qBraUAqVuVTcvvH7YdVi1qNDwdwTR9sC2HXeLDNf6ezm2btt02dsYyLfARcHwDBfw0YU9PaqNA56NAPscnKopQyK8auH0mHe0c</recordid><startdate>20200706</startdate><enddate>20200706</enddate><creator>Cardoso, Felipe Esdras Lucas</creator><creator>Dos Santos, Leandro da Cruz Melgaço</creator><creator>Tenório, Adirlene Pontes de Oliveira</creator><creator>Lopes, Matheus Rodrigues</creator><creator>Barbosa, Romero Henrique de Almeida</creator><general>Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)</general><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200706</creationdate><title>Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease</title><author>Cardoso, Felipe Esdras Lucas ; Dos Santos, Leandro da Cruz Melgaço ; Tenório, Adirlene Pontes de Oliveira ; Lopes, Matheus Rodrigues ; Barbosa, Romero Henrique de Almeida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p158t-7ece99f497dab497cc3e22f8a1edae36fbc1761fc5fa28f864a6e8ad89fa9c063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cardoso, Felipe Esdras Lucas</creatorcontrib><creatorcontrib>Dos Santos, Leandro da Cruz Melgaço</creatorcontrib><creatorcontrib>Tenório, Adirlene Pontes de Oliveira</creatorcontrib><creatorcontrib>Lopes, Matheus Rodrigues</creatorcontrib><creatorcontrib>Barbosa, Romero Henrique de Almeida</creatorcontrib><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Jornal vascular brasileiro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cardoso, Felipe Esdras Lucas</au><au>Dos Santos, Leandro da Cruz Melgaço</au><au>Tenório, Adirlene Pontes de Oliveira</au><au>Lopes, Matheus Rodrigues</au><au>Barbosa, Romero Henrique de Almeida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease</atitle><jtitle>Jornal vascular brasileiro</jtitle><date>2020-07-06</date><risdate>2020</risdate><volume>19</volume><spage>e20190150</spage><epage>e20190150</epage><pages>e20190150-e20190150</pages><issn>1677-5449</issn><eissn>1677-7301</eissn><abstract>Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the
interest of researchers since studies have shown that its effects are not restricted
to bone metabolism. Thus, the present review summarizes the most recent findings and
discusses the usefulness of prescribing vitamin D and its analogues for treatment and
prevention of cardiovascular disorders and endothelial dysfunction. The paper
constitutes a narrative review of the literature, selecting articles published from
2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial
effects on endothelial function, but these results are controversial, since research
with larger samples and of longer duration found no reduction in morbidity and
mortality or cardiovascular risk factors after use of these substances. Given the
current state of the art, there is no clear scientific basis for supplementation with
vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular
disease.</abstract><pub>Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)</pub><pmid>34178073</pmid><doi>10.1590/1677-5449.190150</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1677-5449 |
| ispartof | Jornal vascular brasileiro, 2020-07, Vol.19, p.e20190150-e20190150 |
| issn | 1677-5449 1677-7301 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Review |
| title | Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease |
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