TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, which is refractory to all currently available treatments and bears dismal prognosis. About 70% of all PDAC cases harbor mutations in the TP53 tumor suppressor gene. Many of those are missense mutations, resulting in abundant product...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-06, Vol.118 (23), p.1-9
Hauptverfasser:	Maddalena, Martino, Mallel, Giuseppe, Nataraj, Nishanth Belugali, Shreberk-Shaked, Michal, Hassin, Ori, Mukherjee, Saptaparna, Arandkar, Sharathchandra, Rotkopf, Ron, Kapsack, Abby, Lambiase, Giuseppina, Pellegrino, Bianca, Ben-Isaac, Eyal, Golani, Ofra, Addadi, Yoseph, Hajaj, Emma, Eilam, Raya, Straussman, Ravid, Yarden, Yosef, Lotem, Michal, Oren, Moshe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Animals Biological Sciences Cancer Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology CD8 antigen CD8-Positive T-Lymphocytes Cell Line, Tumor Fibrosis Gene expression Gene silencing Genomes Humans Immune system Infiltration Lymphocytes Lymphocytes T Male Metastases Mice Mice, Inbred C57BL Missense mutation Mutants Mutation Mutation, Missense p53 Protein Pancreas Pancreatic Neoplasms Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Prognosis Tumor microenvironment Tumor Microenvironment - immunology Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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