Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I

The natural product cepafungin I was recently reported to be one of the most potent covalent inhibitors of the 20S proteasome core particle through a series of in vitro activity assays. Here, we report a short chemoenzymatic total synthesis of cepafungin I featuring the use of a regioselective enzym...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell chemical biology 2020-10, Vol.27 (10), p.1318-1326.e18
Hauptverfasser:	Amatuni, Alexander, Shuster, Anton, Adibekian, Alexander, Renata, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	chemoenzymatic synthesis chemoproteomics covalent inhibitor natural product proteasome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!