Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation

Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging disease Hutchinson–Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects on NAT10-catalyze...

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Veröffentlicht in:	ACS medicinal chemistry letters 2021-06, Vol.12 (6), p.887-892
Hauptverfasser:	Shrimp, Jonathan H, Jing, Yihang, Gamage, Supuni Thalalla, Nelson, Kathryn M, Han, Joseph, Bryson, Keri M, Montgomery, David C, Thomas, Justin M, Nance, Kellie D, Sharma, Sunny, Fox, Stephen D, Andressen, Thorkell, Sinclair, Wilson R, Wu, Hong, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Lafontaine, Denis, Dahlin, Jayme L, Marmorstein, Ronen, Walters, Michael A, Meier, Jordan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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