Cell Plasticity and Prostate Cancer: The Role of Epithelial–Mesenchymal Transition in Tumor Progression, Invasion, Metastasis and Cancer Therapy Resistance

Prostate cancer, the second most common malignancy in men, is characterized by high heterogeneity that poses several therapeutic challenges. Epithelial–mesenchymal transition (EMT) is a dynamic, reversible cellular process which is essential in normal embryonic morphogenesis and wound healing. Howev...

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Veröffentlicht in:	Cancers 2021-06, Vol.13 (11), p.2795
Hauptverfasser:	Papanikolaou, Sofia, Vourda, Aikaterini, Syggelos, Spyros, Gyftopoulos, Kostis
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer therapies Cell adhesion Cyclin-dependent kinases Embryogenesis Epigenetics Gene expression Genotype & phenotype Growth factors Kinases Ligands Malignancy Medical prognosis Mesenchyme Metastases Metastasis Morphogenesis Morphology Mortality Phenotypes Plasticity Prostate cancer Proteins Review Transcription factors Tumor cells Tumors Wound healing
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