Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix
The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. W...
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| Veröffentlicht in: | Cancers 2021-05, Vol.13 (11), p.2713 |
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| creator | Okonogi, Noriyuki Ando, Ken Murata, Kazutoshi Wakatsuki, Masaru Noda, Shin-ei Irie, Daisuke Tsuji, Hiroshi Shozu, Makio Ohno, Tatsuya |
| description | The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor. |
| doi_str_mv | 10.3390/cancers13112713 |
| format | Article |
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To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13112713</identifier><identifier>PMID: 34072676</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Adenocarcinoma ; Bone marrow ; Brachytherapy ; Cancer therapies ; Carbon ; Cervical cancer ; Cervix ; Cisplatin ; Clinical outcomes ; Gynecology ; Lymphatic system ; Medical prognosis ; Metastasis ; Multivariate analysis ; Patients ; Radiation therapy ; Rectum ; Surgery ; Survival ; Tumors ; Uterus</subject><ispartof>Cancers, 2021-05, Vol.13 (11), p.2713</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-ce66dcf0e78f55cc21e2dee74961b75231aee4deab220e9af9eed85660bb87d93</citedby><cites>FETCH-LOGICAL-c442t-ce66dcf0e78f55cc21e2dee74961b75231aee4deab220e9af9eed85660bb87d93</cites><orcidid>0000-0003-4011-622X ; 0000-0002-7247-2205 ; 0000-0003-1836-6353 ; 0000-0002-6703-3144 ; 0000-0002-1249-2546 ; 0000-0002-9486-1922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198465/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198465/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids></links><search><creatorcontrib>Okonogi, Noriyuki</creatorcontrib><creatorcontrib>Ando, Ken</creatorcontrib><creatorcontrib>Murata, Kazutoshi</creatorcontrib><creatorcontrib>Wakatsuki, Masaru</creatorcontrib><creatorcontrib>Noda, Shin-ei</creatorcontrib><creatorcontrib>Irie, Daisuke</creatorcontrib><creatorcontrib>Tsuji, Hiroshi</creatorcontrib><creatorcontrib>Shozu, Makio</creatorcontrib><creatorcontrib>Ohno, Tatsuya</creatorcontrib><title>Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix</title><title>Cancers</title><description>The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.</description><subject>Adenocarcinoma</subject><subject>Bone marrow</subject><subject>Brachytherapy</subject><subject>Cancer therapies</subject><subject>Carbon</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>Cisplatin</subject><subject>Clinical outcomes</subject><subject>Gynecology</subject><subject>Lymphatic system</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Rectum</subject><subject>Surgery</subject><subject>Survival</subject><subject>Tumors</subject><subject>Uterus</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdUU1vEzEQtRCordqee7XEhctSf-za6wtSFAGNFERV0bPltWeJq40dbG8gP4L_XIdWCDqXGb158-ZpBqErSt5zrsi1NcFCypRTyiTlr9AZI5I1Qqj29T_1KbrM-YHU4JxKIU_QKW9rU0hxhn5_mafim1XIxZe5-BjMhO-gpJh3YIvfA15U6JB9xnHES5OGGJpVDPjOOB_LBpLZHfAYE741xUMoGf_0ZYPX0ZppOuCF2x9tulpAqFiyPsStOYrVYXxfIPkAeAlp739doDejmTJcPudzdP_p47flTbP--nm1XKwb27asNBaEcHYkIPux66xlFJgDkK0SdJAd49QAtA7MwBgBZUYF4PpOCDIMvXSKn6MPT7q7ediCs9V2MpPeJb816aCj8fr_TvAb_T3udU9V34quCrx7Fkjxxwy56K3PFqbJBIhz1qzjopWU0OOuty-oD3FO9aZ_WEqQTom-sq6fWLZePicY_5qhRB-_rV98mz8CYwahhg</recordid><startdate>20210531</startdate><enddate>20210531</enddate><creator>Okonogi, Noriyuki</creator><creator>Ando, Ken</creator><creator>Murata, Kazutoshi</creator><creator>Wakatsuki, Masaru</creator><creator>Noda, Shin-ei</creator><creator>Irie, Daisuke</creator><creator>Tsuji, Hiroshi</creator><creator>Shozu, Makio</creator><creator>Ohno, Tatsuya</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4011-622X</orcidid><orcidid>https://orcid.org/0000-0002-7247-2205</orcidid><orcidid>https://orcid.org/0000-0003-1836-6353</orcidid><orcidid>https://orcid.org/0000-0002-6703-3144</orcidid><orcidid>https://orcid.org/0000-0002-1249-2546</orcidid><orcidid>https://orcid.org/0000-0002-9486-1922</orcidid></search><sort><creationdate>20210531</creationdate><title>Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix</title><author>Okonogi, Noriyuki ; 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To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB–IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m2 per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>34072676</pmid><doi>10.3390/cancers13112713</doi><orcidid>https://orcid.org/0000-0003-4011-622X</orcidid><orcidid>https://orcid.org/0000-0002-7247-2205</orcidid><orcidid>https://orcid.org/0000-0003-1836-6353</orcidid><orcidid>https://orcid.org/0000-0002-6703-3144</orcidid><orcidid>https://orcid.org/0000-0002-1249-2546</orcidid><orcidid>https://orcid.org/0000-0002-9486-1922</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Bone marrow Brachytherapy Cancer therapies Carbon Cervical cancer Cervix Cisplatin Clinical outcomes Gynecology Lymphatic system Medical prognosis Metastasis Multivariate analysis Patients Radiation therapy Rectum Surgery Survival Tumors Uterus |
| title | Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix |
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