Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development

Nephrogenesis is driven by complex signaling pathways that control cell growth and differentiation. The endoplasmic reticulum chaperone calreticulin (Calr) is well known for its function in calcium storage and in the folding of glycoproteins. Its role in kidney development is still not understood. W...

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Veröffentlicht in:	International journal of molecular sciences 2021-05, Vol.22 (11), p.5858
Hauptverfasser:	Serin, Nazli, Dihazi, Gry H, Tayyeb, Asima, Lenz, Christof, Müller, Gerhard A, Zeisberg, Michael, Dihazi, Hassan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Signaling Calreticulin - deficiency Calreticulin - genetics Embryo, Mammalian Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Female Gene Expression Regulation, Developmental Glycoproteins - classification Glycoproteins - genetics Glycoproteins - metabolism Kidney - growth & development Kidney - metabolism Kidney - pathology Mice Mice, Inbred C57BL Mice, Knockout Organelle Biogenesis Organogenesis - genetics Protein Folding Proteomics - methods Ribosomal Proteins - deficiency Ribosomal Proteins - genetics Ribosomes - genetics Ribosomes - metabolism Ribosomes - pathology Wnt Signaling Pathway
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