New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines
Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk catego...
Gespeichert in:
| Veröffentlicht in: | Cancers 2021-05, Vol.13 (11), p.2623 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 11 |
| container_start_page | 2623 |
| container_title | Cancers |
| container_volume | 13 |
| creator | Santoro, Angela Angelico, Giuseppe Travaglino, Antonio Inzani, Frediano Arciuolo, Damiano Valente, Michele D'Alessandris, Nicoletta Scaglione, Giulia Fiorentino, Vincenzo Raffone, Antonio Zannoni, Gian Franco |
| description | Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk categories, and guiding surgical and adjuvant therapy. In 2013, The Cancer Genome Atlas (TCGA) Research Network reported a large scale molecular analysis of 373 endometrial carcinomas which demonstrated four categories with distinct clinical, pathologic, and molecular features: POLE/ultramutated (7% of cases) microsatellite instability (MSI)/hypermutated (28%), copy-number low/endometrioid (39%), and copy-number high/serous-like (26%). In the present article, we report a detailed histological and molecular review of all endometrial carcinoma histotypes in light of the current ESGO/ESTRO/ESP guidelines. In particular, we focus on the distribution and prognostic value of the TCGA groups in each histotype. |
| doi_str_mv | 10.3390/cancers13112623 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8198052</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2539606018</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-b3ef0b2afebc63da905ad1b2fbb8301ae823eb8c9381f6feb514c69d93a7dda23</originalsourceid><addsrcrecordid>eNpdkU1r3DAQhkVpaEKac2_F0Esv25U0tmxdCmXZbgOhCfnoVcjSeFfBlraS3ZB_XzlJQxod9DHzzKsZXkI-MPoFQNKl0d5gTAwY44LDG3LEac0XQsjy7Yv7ITlJ6ZbmBcBqUb8jh1DSGgRUR2T4iXfFhR53oQ9bZ3RfaG-LVe_8w-PUJ7fdjalwvlh7GwYco8vx1cPXc_SXywKhK8YdFjd7q0e0xfpqc75cX11fzvtFsZmcxayI6T056HSf8OTpPCY339fXqx-Ls_PN6erb2cKUnI2LFrCjLdcdtkaA1ZJW2rKWd23bAGUaGw7YNkZCwzqRqYqVRkgrQdfWag7H5Ouj7n5qB7QG_Rh1r_bRDTreq6Cd-j_j3U5twx_VMNnQahb4_CQQw-8J06gGlwz2vfYYpqR4BaKUJYM6o59eobdhij6PN1NSUEFZk6nlI2ViSCli99wMo2p2U71yM1d8fDnDM__PO_gLmFec1w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2539606018</pqid></control><display><type>article</type><title>New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Santoro, Angela ; Angelico, Giuseppe ; Travaglino, Antonio ; Inzani, Frediano ; Arciuolo, Damiano ; Valente, Michele ; D'Alessandris, Nicoletta ; Scaglione, Giulia ; Fiorentino, Vincenzo ; Raffone, Antonio ; Zannoni, Gian Franco</creator><creatorcontrib>Santoro, Angela ; Angelico, Giuseppe ; Travaglino, Antonio ; Inzani, Frediano ; Arciuolo, Damiano ; Valente, Michele ; D'Alessandris, Nicoletta ; Scaglione, Giulia ; Fiorentino, Vincenzo ; Raffone, Antonio ; Zannoni, Gian Franco</creatorcontrib><description>Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk categories, and guiding surgical and adjuvant therapy. In 2013, The Cancer Genome Atlas (TCGA) Research Network reported a large scale molecular analysis of 373 endometrial carcinomas which demonstrated four categories with distinct clinical, pathologic, and molecular features: POLE/ultramutated (7% of cases) microsatellite instability (MSI)/hypermutated (28%), copy-number low/endometrioid (39%), and copy-number high/serous-like (26%). In the present article, we report a detailed histological and molecular review of all endometrial carcinoma histotypes in light of the current ESGO/ESTRO/ESP guidelines. In particular, we focus on the distribution and prognostic value of the TCGA groups in each histotype.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers13112623</identifier><identifier>PMID: 34073635</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Carcinoma ; Classification ; Endometrial cancer ; Endometrium ; Genomes ; Integrated approach ; Medical prognosis ; Microsatellite instability ; Mutation ; Review ; Tumors</subject><ispartof>Cancers, 2021-05, Vol.13 (11), p.2623</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-b3ef0b2afebc63da905ad1b2fbb8301ae823eb8c9381f6feb514c69d93a7dda23</citedby><cites>FETCH-LOGICAL-c421t-b3ef0b2afebc63da905ad1b2fbb8301ae823eb8c9381f6feb514c69d93a7dda23</cites><orcidid>0000-0002-1132-1761 ; 0000-0002-6964-5152 ; 0000-0002-9061-6989 ; 0000-0001-5443-2333 ; 0000-0003-4808-2052 ; 0000-0002-4473-7560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198052/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198052/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34073635$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santoro, Angela</creatorcontrib><creatorcontrib>Angelico, Giuseppe</creatorcontrib><creatorcontrib>Travaglino, Antonio</creatorcontrib><creatorcontrib>Inzani, Frediano</creatorcontrib><creatorcontrib>Arciuolo, Damiano</creatorcontrib><creatorcontrib>Valente, Michele</creatorcontrib><creatorcontrib>D'Alessandris, Nicoletta</creatorcontrib><creatorcontrib>Scaglione, Giulia</creatorcontrib><creatorcontrib>Fiorentino, Vincenzo</creatorcontrib><creatorcontrib>Raffone, Antonio</creatorcontrib><creatorcontrib>Zannoni, Gian Franco</creatorcontrib><title>New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk categories, and guiding surgical and adjuvant therapy. In 2013, The Cancer Genome Atlas (TCGA) Research Network reported a large scale molecular analysis of 373 endometrial carcinomas which demonstrated four categories with distinct clinical, pathologic, and molecular features: POLE/ultramutated (7% of cases) microsatellite instability (MSI)/hypermutated (28%), copy-number low/endometrioid (39%), and copy-number high/serous-like (26%). In the present article, we report a detailed histological and molecular review of all endometrial carcinoma histotypes in light of the current ESGO/ESTRO/ESP guidelines. In particular, we focus on the distribution and prognostic value of the TCGA groups in each histotype.</description><subject>Carcinoma</subject><subject>Classification</subject><subject>Endometrial cancer</subject><subject>Endometrium</subject><subject>Genomes</subject><subject>Integrated approach</subject><subject>Medical prognosis</subject><subject>Microsatellite instability</subject><subject>Mutation</subject><subject>Review</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1r3DAQhkVpaEKac2_F0Esv25U0tmxdCmXZbgOhCfnoVcjSeFfBlraS3ZB_XzlJQxod9DHzzKsZXkI-MPoFQNKl0d5gTAwY44LDG3LEac0XQsjy7Yv7ITlJ6ZbmBcBqUb8jh1DSGgRUR2T4iXfFhR53oQ9bZ3RfaG-LVe_8w-PUJ7fdjalwvlh7GwYco8vx1cPXc_SXywKhK8YdFjd7q0e0xfpqc75cX11fzvtFsZmcxayI6T056HSf8OTpPCY339fXqx-Ls_PN6erb2cKUnI2LFrCjLdcdtkaA1ZJW2rKWd23bAGUaGw7YNkZCwzqRqYqVRkgrQdfWag7H5Ouj7n5qB7QG_Rh1r_bRDTreq6Cd-j_j3U5twx_VMNnQahb4_CQQw-8J06gGlwz2vfYYpqR4BaKUJYM6o59eobdhij6PN1NSUEFZk6nlI2ViSCli99wMo2p2U71yM1d8fDnDM__PO_gLmFec1w</recordid><startdate>20210526</startdate><enddate>20210526</enddate><creator>Santoro, Angela</creator><creator>Angelico, Giuseppe</creator><creator>Travaglino, Antonio</creator><creator>Inzani, Frediano</creator><creator>Arciuolo, Damiano</creator><creator>Valente, Michele</creator><creator>D'Alessandris, Nicoletta</creator><creator>Scaglione, Giulia</creator><creator>Fiorentino, Vincenzo</creator><creator>Raffone, Antonio</creator><creator>Zannoni, Gian Franco</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1132-1761</orcidid><orcidid>https://orcid.org/0000-0002-6964-5152</orcidid><orcidid>https://orcid.org/0000-0002-9061-6989</orcidid><orcidid>https://orcid.org/0000-0001-5443-2333</orcidid><orcidid>https://orcid.org/0000-0003-4808-2052</orcidid><orcidid>https://orcid.org/0000-0002-4473-7560</orcidid></search><sort><creationdate>20210526</creationdate><title>New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines</title><author>Santoro, Angela ; Angelico, Giuseppe ; Travaglino, Antonio ; Inzani, Frediano ; Arciuolo, Damiano ; Valente, Michele ; D'Alessandris, Nicoletta ; Scaglione, Giulia ; Fiorentino, Vincenzo ; Raffone, Antonio ; Zannoni, Gian Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-b3ef0b2afebc63da905ad1b2fbb8301ae823eb8c9381f6feb514c69d93a7dda23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carcinoma</topic><topic>Classification</topic><topic>Endometrial cancer</topic><topic>Endometrium</topic><topic>Genomes</topic><topic>Integrated approach</topic><topic>Medical prognosis</topic><topic>Microsatellite instability</topic><topic>Mutation</topic><topic>Review</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santoro, Angela</creatorcontrib><creatorcontrib>Angelico, Giuseppe</creatorcontrib><creatorcontrib>Travaglino, Antonio</creatorcontrib><creatorcontrib>Inzani, Frediano</creatorcontrib><creatorcontrib>Arciuolo, Damiano</creatorcontrib><creatorcontrib>Valente, Michele</creatorcontrib><creatorcontrib>D'Alessandris, Nicoletta</creatorcontrib><creatorcontrib>Scaglione, Giulia</creatorcontrib><creatorcontrib>Fiorentino, Vincenzo</creatorcontrib><creatorcontrib>Raffone, Antonio</creatorcontrib><creatorcontrib>Zannoni, Gian Franco</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santoro, Angela</au><au>Angelico, Giuseppe</au><au>Travaglino, Antonio</au><au>Inzani, Frediano</au><au>Arciuolo, Damiano</au><au>Valente, Michele</au><au>D'Alessandris, Nicoletta</au><au>Scaglione, Giulia</au><au>Fiorentino, Vincenzo</au><au>Raffone, Antonio</au><au>Zannoni, Gian Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2021-05-26</date><risdate>2021</risdate><volume>13</volume><issue>11</issue><spage>2623</spage><pages>2623-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Endometrial carcinoma represents the most common gynecological cancer in Europe and the USA. Histopathological classification based on tumor morphology and tumor grade has played a crucial role in the management of endometrial carcinoma, allowing a prognostic stratification into distinct risk categories, and guiding surgical and adjuvant therapy. In 2013, The Cancer Genome Atlas (TCGA) Research Network reported a large scale molecular analysis of 373 endometrial carcinomas which demonstrated four categories with distinct clinical, pathologic, and molecular features: POLE/ultramutated (7% of cases) microsatellite instability (MSI)/hypermutated (28%), copy-number low/endometrioid (39%), and copy-number high/serous-like (26%). In the present article, we report a detailed histological and molecular review of all endometrial carcinoma histotypes in light of the current ESGO/ESTRO/ESP guidelines. In particular, we focus on the distribution and prognostic value of the TCGA groups in each histotype.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34073635</pmid><doi>10.3390/cancers13112623</doi><orcidid>https://orcid.org/0000-0002-1132-1761</orcidid><orcidid>https://orcid.org/0000-0002-6964-5152</orcidid><orcidid>https://orcid.org/0000-0002-9061-6989</orcidid><orcidid>https://orcid.org/0000-0001-5443-2333</orcidid><orcidid>https://orcid.org/0000-0003-4808-2052</orcidid><orcidid>https://orcid.org/0000-0002-4473-7560</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2021-05, Vol.13 (11), p.2623 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8198052 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Carcinoma Classification Endometrial cancer Endometrium Genomes Integrated approach Medical prognosis Microsatellite instability Mutation Review Tumors |
| title | New Pathological and Clinical Insights in Endometrial Cancer in View of the Updated ESGO/ESTRO/ESP Guidelines |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T05%3A11%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20Pathological%20and%20Clinical%20Insights%20in%20Endometrial%20Cancer%20in%20View%20of%20the%20Updated%20ESGO/ESTRO/ESP%20Guidelines&rft.jtitle=Cancers&rft.au=Santoro,%20Angela&rft.date=2021-05-26&rft.volume=13&rft.issue=11&rft.spage=2623&rft.pages=2623-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers13112623&rft_dat=%3Cproquest_pubme%3E2539606018%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2539606018&rft_id=info:pmid/34073635&rfr_iscdi=true |