Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines
An effective vaccine for human immunodeficiency virus（HIV） is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome（AIDS）. As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attrac...
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| Veröffentlicht in: | Virologica Sinica 2016-04, Vol.31 (2), p.110-117 |
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| container_title | Virologica Sinica |
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| creator | Wang, Zhenyuan Qin, Chunjun Hu, Jing Guo, Xiaoqiang Yin, Jian |
| description | An effective vaccine for human immunodeficiency virus（HIV） is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome（AIDS）. As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV. |
| doi_str_mv | 10.1007/s12250-015-3691-3 |
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As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.</description><identifier>ISSN: 1674-0769</identifier><identifier>EISSN: 1995-820X</identifier><identifier>DOI: 10.1007/s12250-015-3691-3</identifier><identifier>PMID: 26992403</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Antibodies, Neutralizing - immunology ; Antiretroviral drugs ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Carbohydrates ; Carbohydrates - chemical synthesis ; Carbohydrates - chemistry ; Carbohydrates - immunology ; Drug Design ; Glycoproteins - chemistry ; Glycoproteins - immunology ; Glycosylation ; HIV ; HIV Antibodies - blood ; HIV Antibodies - immunology ; HIV Infections - immunology ; HIV Infections - prevention & control ; HIV Infections - virology ; HIV-1 - chemistry ; HIV-1 - genetics ; HIV-1 - immunology ; Human immunodeficiency virus ; Humans ; Immunogenicity ; Medical Microbiology ; Microbial Genetics and Genomics ; Microbiology ; Oligosaccharides - chemical synthesis ; Oligosaccharides - chemistry ; Oncology ; Review ; Vaccines ; Vaccines, Subunit - chemistry ; Vaccines, Subunit - immunology ; Vaccines, Synthetic - chemistry ; Vaccines, Synthetic - immunology ; Viral Core Proteins - genetics ; Viral Core Proteins - immunology ; Virology ; 人类免疫缺陷病毒 ; 合成 ; 基础 ; 抗病毒疫苗 ; 病毒感染 ; 病毒蛋白 ; 碳水化合物 ; 艾滋病毒</subject><ispartof>Virologica Sinica, 2016-04, Vol.31 (2), p.110-117</ispartof><rights>Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2016</rights><rights>Wuhan Institute of Virology, CAS and Springer Science+Business Media Singapore 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-94a6490604a7d4abf4ffb1f47f1212cf1715e998a9d455e2e4c9380e023cb4f3</citedby><cites>FETCH-LOGICAL-c497t-94a6490604a7d4abf4ffb1f47f1212cf1715e998a9d455e2e4c9380e023cb4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/92590B/92590B.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193421/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193421/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26992403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Zhenyuan</creatorcontrib><creatorcontrib>Qin, Chunjun</creatorcontrib><creatorcontrib>Hu, Jing</creatorcontrib><creatorcontrib>Guo, Xiaoqiang</creatorcontrib><creatorcontrib>Yin, Jian</creatorcontrib><title>Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines</title><title>Virologica Sinica</title><addtitle>Virol. Sin</addtitle><addtitle>Virologica Sinica</addtitle><description>An effective vaccine for human immunodeficiency virus（HIV） is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome（AIDS）. As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antiretroviral drugs</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Carbohydrates</subject><subject>Carbohydrates - chemical synthesis</subject><subject>Carbohydrates - chemistry</subject><subject>Carbohydrates - immunology</subject><subject>Drug Design</subject><subject>Glycoproteins - chemistry</subject><subject>Glycoproteins - immunology</subject><subject>Glycosylation</subject><subject>HIV</subject><subject>HIV Antibodies - blood</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Infections - immunology</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - chemistry</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunogenicity</subject><subject>Medical Microbiology</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Oligosaccharides - chemical synthesis</subject><subject>Oligosaccharides - chemistry</subject><subject>Oncology</subject><subject>Review</subject><subject>Vaccines</subject><subject>Vaccines, Subunit - chemistry</subject><subject>Vaccines, Subunit - immunology</subject><subject>Vaccines, Synthetic - chemistry</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Viral Core Proteins - genetics</subject><subject>Viral Core Proteins - immunology</subject><subject>Virology</subject><subject>人类免疫缺陷病毒</subject><subject>合成</subject><subject>基础</subject><subject>抗病毒疫苗</subject><subject>病毒感染</subject><subject>病毒蛋白</subject><subject>碳水化合物</subject><subject>艾滋病毒</subject><issn>1674-0769</issn><issn>1995-820X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlrHDEUhEWIiZfkB-QSmuTiS8faWsslEEw2MBiMA7kJtfppWmZasqXugfn30TCTyXLISYL3VemVCqHXBL8nGMurQijtcItJ1zKhScueoTOiddcqin88r3cheYul0KfovJQHjAVVjL1Ap1RoTTlmZ-j7HTiIc2OHjY0OShNiU7ZxHmEOrnE292ncDtnO0Pa2wNCMy2RjE6ZpiWkAH1yA6LbNJuSlNBvrXIhQXqITb9cFXh3OC3T_-dP99df25vbLt-uPN63jWs6t5lZwjQXmVg7c9p573xPPpSeUUOeJJB1oraweeNcBBe40UxgwZa7nnl2gD3vbx6WfYNgFyXZtHnOYbN6aZIP5exLDaFZpYxTRjFNSDS4PBjk9LVBmM4XiYL22EdJSDJGqk1xxgSv67h_0IS051nSm_iRnWnZEVYrsKZdTKRn8cRmCza4zs-_M1M7MrjPDqubNnymOil8lVYDugVJHcQX599P_c3172GRMcfVUdUdjIZSSGKuO_QQM4q7b</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Wang, Zhenyuan</creator><creator>Qin, Chunjun</creator><creator>Hu, Jing</creator><creator>Guo, Xiaoqiang</creator><creator>Yin, Jian</creator><general>Springer Singapore</general><general>KeAi Publishing Communications Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160401</creationdate><title>Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines</title><author>Wang, Zhenyuan ; Qin, Chunjun ; Hu, Jing ; Guo, Xiaoqiang ; Yin, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-94a6490604a7d4abf4ffb1f47f1212cf1715e998a9d455e2e4c9380e023cb4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Antibodies, Neutralizing - immunology</topic><topic>Antiretroviral drugs</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Carbohydrates</topic><topic>Carbohydrates - chemical synthesis</topic><topic>Carbohydrates - chemistry</topic><topic>Carbohydrates - immunology</topic><topic>Drug Design</topic><topic>Glycoproteins - chemistry</topic><topic>Glycoproteins - immunology</topic><topic>Glycosylation</topic><topic>HIV</topic><topic>HIV Antibodies - blood</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Infections - immunology</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - chemistry</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunogenicity</topic><topic>Medical Microbiology</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Oligosaccharides - chemical synthesis</topic><topic>Oligosaccharides - chemistry</topic><topic>Oncology</topic><topic>Review</topic><topic>Vaccines</topic><topic>Vaccines, Subunit - chemistry</topic><topic>Vaccines, Subunit - immunology</topic><topic>Vaccines, Synthetic - chemistry</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Viral Core Proteins - genetics</topic><topic>Viral Core Proteins - immunology</topic><topic>Virology</topic><topic>人类免疫缺陷病毒</topic><topic>合成</topic><topic>基础</topic><topic>抗病毒疫苗</topic><topic>病毒感染</topic><topic>病毒蛋白</topic><topic>碳水化合物</topic><topic>艾滋病毒</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Zhenyuan</creatorcontrib><creatorcontrib>Qin, Chunjun</creatorcontrib><creatorcontrib>Hu, Jing</creatorcontrib><creatorcontrib>Guo, Xiaoqiang</creatorcontrib><creatorcontrib>Yin, Jian</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Virologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Zhenyuan</au><au>Qin, Chunjun</au><au>Hu, Jing</au><au>Guo, Xiaoqiang</au><au>Yin, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines</atitle><jtitle>Virologica Sinica</jtitle><stitle>Virol. Sin</stitle><addtitle>Virologica Sinica</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>31</volume><issue>2</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>1674-0769</issn><eissn>1995-820X</eissn><abstract>An effective vaccine for human immunodeficiency virus（HIV） is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome（AIDS）. As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. 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| ispartof | Virologica Sinica, 2016-04, Vol.31 (2), p.110-117 |
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| language | eng |
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| subjects | Acquired immune deficiency syndrome AIDS Antibodies, Neutralizing - immunology Antiretroviral drugs Biochemistry Biomedical and Life Sciences Biomedicine Carbohydrates Carbohydrates - chemical synthesis Carbohydrates - chemistry Carbohydrates - immunology Drug Design Glycoproteins - chemistry Glycoproteins - immunology Glycosylation HIV HIV Antibodies - blood HIV Antibodies - immunology HIV Infections - immunology HIV Infections - prevention & control HIV Infections - virology HIV-1 - chemistry HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus Humans Immunogenicity Medical Microbiology Microbial Genetics and Genomics Microbiology Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oncology Review Vaccines Vaccines, Subunit - chemistry Vaccines, Subunit - immunology Vaccines, Synthetic - chemistry Vaccines, Synthetic - immunology Viral Core Proteins - genetics Viral Core Proteins - immunology Virology 人类免疫缺陷病毒 合成 基础 抗病毒疫苗 病毒感染 病毒蛋白 碳水化合物 艾滋病毒 |
| title | Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines |
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