Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

SARS‐CoV‐2 has become a pandemic worldwide; therefore, an effective vaccine is urgently needed. Recently, messenger RNAs (mRNAs) have emerged as a promising platform for vaccination. In this work, the untranslated regions (UTRs) of mRNAs are systematically engineered in order to enhance protein prod...

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Veröffentlicht in:	Advanced materials (Weinheim) 2020-10, Vol.32 (40), p.e2004452-n/a
Hauptverfasser:	Zeng, Chunxi, Hou, Xucheng, Yan, Jingyue, Zhang, Chengxiang, Li, Wenqing, Zhao, Weiyu, Du, Shi, Dong, Yizhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral - metabolism Antigens Antigens, Viral - administration & dosage Betacoronavirus - immunology Cell Line, Tumor Coronavirus Infections - prevention & control COVID-19 Vaccines Female Gene Expression Gene sequencing HEK293 Cells Humans Lipids lipid‐derived nanoparticles Materials science Mice, Inbred C57BL mRNA engineering mRNA vaccines Nanoparticles RNA, Messenger SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 untranslated regions Vaccination Vaccines Viral Vaccines
Online-Zugang:	Volltext
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