Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress

Abstract Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent inhibitor of aminoacylation of tRNAPro with broad biomedical applications. Here, we show that in addition to trans...

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Veröffentlicht in:	Nucleic acids research 2021-06, Vol.49 (10), p.5726-5742
Hauptverfasser:	Misra, Jagannath, Holmes, Michael J, T. Mirek, Emily, Langevin, Michael, Kim, Hyeong-Geug, Carlson, Kenneth R, Watford, Malcolm, Dong, X Charlie, Anthony, Tracy G, Wek, Ronald C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Cell Survival - genetics Cells, Cultured Codon - genetics Gene Ontology Liver - drug effects Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Molecular Biology Phosphorylation Piperidines - administration & dosage Piperidines - pharmacology Polyribosomes - metabolism Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein Synthesis Inhibitors - administration & dosage Protein Synthesis Inhibitors - pharmacology Quinazolinones - administration & dosage Quinazolinones - pharmacology RNA, Transfer - genetics RNA, Transfer - metabolism Signal Transduction - drug effects Signal Transduction - genetics Stress, Physiological - drug effects Stress, Physiological - genetics
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