m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin

Abstract Heterochromatin has essential functions in maintaining chromosome structure, in protecting genome integrity and in stabilizing gene expression programs. Heterochromatin is often nucleated by underlying DNA repeat sequences, such as major satellite repeats (MSR) and long interspersed nuclear...

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Veröffentlicht in:	Nucleic acids research 2021-06, Vol.49 (10), p.5568-5587
Hauptverfasser:	Duda, Katarzyna J, Ching, Reagan W, Jerabek, Lisa, Shukeir, Nicholas, Erikson, Galina, Engist, Bettina, Onishi-Seebacher, Megumi, Perrera, Valentina, Richter, Florian, Mittler, Gerhard, Fritz, Katharina, Helm, Mark, Knuckles, Philip, Bühler, Marc, Jenuwein, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - metabolism Animals DNA - metabolism Gene regulation, Chromatin and Epigenetics Heterochromatin Methylation Mice Mouse Embryonic Stem Cells RNA - metabolism Tandem Repeat Sequences
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