Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation

Cathepsin H (CTSH) is a type 1 diabetes (T1D) risk gene; large-scale genetic and epidemiological studies found that T1D genetic risk correlates with high CTSH expression, rapid decline of beta-cell function, and early onset T1D. Counterintuitively, transcriptional downregulation of CTSH by proinflam...

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Veröffentlicht in:	The Journal of biological chemistry 2021-01, Vol.296, p.100774-100774, Article 100774
Hauptverfasser:	Ye, Jody, Stefan-Lifshitz, Mihaela, Tomer, Yaron
Format:	Artikel
Sprache:	eng
Schlagworte:	beta cell Cathepsin H - genetics CpG Islands Diabetes Mellitus, Type 1 - genetics DNA Methylation Epigenesis, Genetic epigenetics Gene-Environment Interaction genetic polymorphism Humans type 1 diabetes
Online-Zugang:	Volltext
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