Adjuvant and concurrent temozolomide for 1p/19q non-co-deleted anaplastic glioma (CATNON; EORTC study 26053-22054): second interim analysis of a randomised, open-label, phase 3 study

The CATNON trial investigated the addition of concurrent, adjuvant, and both current and adjuvant temozolomide to radiotherapy in adults with newly diagnosed 1p/19q non-co-deleted anaplastic gliomas. The benefit of concurrent temozolomide chemotherapy and relevance of mutations in the IDH1 and IDH2...

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Veröffentlicht in:	The lancet oncology 2021-06, Vol.22 (6), p.813-823
Hauptverfasser:	van den Bent, Martin J, Tesileanu, C Mircea S, Wick, Wolfgang, Sanson, Marc, Brandes, Alba Ariela, Clement, Paul M, Erridge, Sarah, Vogelbaum, Michael A, Nowak, Anna K, Baurain, Jean Français, Mason, Warren P, Wheeler, Helen, Chinot, Olivier L, Gill, Sanjeev, Griffin, Matthew, Rogers, Leland, Taal, Walter, Rudà, Roberta, Weller, Michael, McBain, Catherine, Reijneveld, Jaap, Enting, Roelien H, Caparrotti, Francesca, Lesimple, Thierry, Clenton, Susan, Gijtenbeek, Anja, Lim, Elizabeth, Herrlinger, Ulrich, Hau, Peter, Dhermain, Frederic, de Heer, Iris, Aldape, Kenneth, Jenkins, Robert B, Dubbink, Hendrikus Jan, Kros, Johan M, Wesseling, Pieter, Nuyens, Sarah, Golfinopoulos, Vassilis, Gorlia, Thierry, French, Pim, Baumert, Brigitta G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Australia Biomarkers Brain cancer Chemotherapy Chemotherapy, Adjuvant Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics Combined Modality Therapy Dacarbazine - administration & dosage Dacarbazine - adverse effects DNA methylation Europe Female Glioma Glioma - drug therapy Glioma - genetics Glioma - pathology Glioma - radiotherapy Hematology Hepatitis Heterozygosity Humans Isocitrate Dehydrogenase - genetics Life Sciences Loss of heterozygosity Loss of Heterozygosity - genetics Male Medical prognosis Middle Aged Mutation North America Patients Quality of life Radiation therapy Radiotherapy, Conformal Survival Temozolomide Temozolomide - administration & dosage Tumors Young Adult
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