Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation

With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago, targeted protein degradation (TPD) has changed the landscape of drug development. PROTACs have evolved from cell-impermeable peptide-small molecule chimeras to orally bioavailable clinical candidate drugs that degrade o...

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Veröffentlicht in:	RSC chemical biology 2021-03, Vol.2 (3), p.725-742
Hauptverfasser:	Bond, Michael J, Crews, Craig M
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
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