Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma

Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma

Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognosti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Asian Pacific Journal of Cancer Prevention 2021-02, Vol.22 (2), p.407-412
Hauptverfasser: Mahmood, Nosheen, Mushtaq, Shamim, Jamal, Qamar, Hanif, Muhammad, Akhlaq, Humera, Rehman, Dur-e-Shewar, Awan, Rashid
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 412
container_issue 2
container_start_page 407
container_title Asian Pacific Journal of Cancer Prevention
container_volume 22
creator Mahmood, Nosheen
Mushtaq, Shamim
Jamal, Qamar
Hanif, Muhammad
Akhlaq, Humera
Rehman, Dur-e-Shewar
Awan, Rashid
description Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognostic relevance of HMGA2 in liquid biopsies of oral cancer patients. After obtaining approval from Institutional Review Board of Ziauddin University and informed written consent from study subjects, expression of circulating HMGA2 was evaluated in 96 OSCC cases and 100 age and sex matched controls via real time PCR using specific set of primers. We further analyzed relationship of various sociodemographic and clinicopathological variables with HMGA2expression and explored its prognostic potential. Expression was seen in 22 (23%) cases. A higher expression was observed among subjects with local invasion (52.6% vs 47.4 %), distant metastasis (71.4% vs 28.6%) and tumor recurrence (57.1% vs 42.9%) p.
doi_str_mv 10.31557/APJCP.2021.22.2.407
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8190352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>33639654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3237-a61764ffb1ee82ccb8994e3eb1112e145eee351480e43917dde0a935d75018583</originalsourceid><addsrcrecordid>eNpVkd1q20AQhZfSUOfvDUrZy_ZCyv5qpZuCKxI7wcGGOtC7ZSWN7K1lrbMrBfIYeePIcRKSqxlmOOcM8yH0nZKYUynVxXhxky9iRhiNGYtZLIj6go6ZUEmkEvbv64d-hE5C-E-IkKmS39CI84RniRTH6GnhOmg7axp819nGdo_Y1TiHpsFXHgBP7WqNb11xWE2863d4vIzWzm0wwz-nt5Mx-4VNwAYvvFu1LnS2xH-s2xq_AY9ti2f2vrfVfrYLFsLef-6HvL_3vdm6PhzScuNL2w6yM3RUmybA-Ws9RXdXl8t8Gs3mk-t8PItKzriKTEJVIuq6oAApK8sizTIBHApKKQMqJABwSUVKQPCMqqoCYjIuKyUJTWXKT9Hvg--uL7ZQlcMXhqv0ztvh9EftjNWfN61d65V70CnNCJdsMBAHg9K7EDzU71pK9Asi_YJI7xFpxjTTA6JB9uNj7rvojQl_BqE7jiw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma</title><source>Freely Accessible Journals</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Mahmood, Nosheen ; Mushtaq, Shamim ; Jamal, Qamar ; Hanif, Muhammad ; Akhlaq, Humera ; Rehman, Dur-e-Shewar ; Awan, Rashid</creator><creatorcontrib>Mahmood, Nosheen ; Mushtaq, Shamim ; Jamal, Qamar ; Hanif, Muhammad ; Akhlaq, Humera ; Rehman, Dur-e-Shewar ; Awan, Rashid</creatorcontrib><description>Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognostic relevance of HMGA2 in liquid biopsies of oral cancer patients. After obtaining approval from Institutional Review Board of Ziauddin University and informed written consent from study subjects, expression of circulating HMGA2 was evaluated in 96 OSCC cases and 100 age and sex matched controls via real time PCR using specific set of primers. We further analyzed relationship of various sociodemographic and clinicopathological variables with HMGA2expression and explored its prognostic potential. Expression was seen in 22 (23%) cases. A higher expression was observed among subjects with local invasion (52.6% vs 47.4 %), distant metastasis (71.4% vs 28.6%) and tumor recurrence (57.1% vs 42.9%) p.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2021.22.2.407</identifier><identifier>PMID: 33639654</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><ispartof>Asian Pacific Journal of Cancer Prevention, 2021-02, Vol.22 (2), p.407-412</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3237-a61764ffb1ee82ccb8994e3eb1112e145eee351480e43917dde0a935d75018583</citedby><orcidid>0000-0002-6269-9457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190352/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190352/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33639654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahmood, Nosheen</creatorcontrib><creatorcontrib>Mushtaq, Shamim</creatorcontrib><creatorcontrib>Jamal, Qamar</creatorcontrib><creatorcontrib>Hanif, Muhammad</creatorcontrib><creatorcontrib>Akhlaq, Humera</creatorcontrib><creatorcontrib>Rehman, Dur-e-Shewar</creatorcontrib><creatorcontrib>Awan, Rashid</creatorcontrib><title>Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognostic relevance of HMGA2 in liquid biopsies of oral cancer patients. After obtaining approval from Institutional Review Board of Ziauddin University and informed written consent from study subjects, expression of circulating HMGA2 was evaluated in 96 OSCC cases and 100 age and sex matched controls via real time PCR using specific set of primers. We further analyzed relationship of various sociodemographic and clinicopathological variables with HMGA2expression and explored its prognostic potential. Expression was seen in 22 (23%) cases. A higher expression was observed among subjects with local invasion (52.6% vs 47.4 %), distant metastasis (71.4% vs 28.6%) and tumor recurrence (57.1% vs 42.9%) p.</description><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVkd1q20AQhZfSUOfvDUrZy_ZCyv5qpZuCKxI7wcGGOtC7ZSWN7K1lrbMrBfIYeePIcRKSqxlmOOcM8yH0nZKYUynVxXhxky9iRhiNGYtZLIj6go6ZUEmkEvbv64d-hE5C-E-IkKmS39CI84RniRTH6GnhOmg7axp819nGdo_Y1TiHpsFXHgBP7WqNb11xWE2863d4vIzWzm0wwz-nt5Mx-4VNwAYvvFu1LnS2xH-s2xq_AY9ti2f2vrfVfrYLFsLef-6HvL_3vdm6PhzScuNL2w6yM3RUmybA-Ws9RXdXl8t8Gs3mk-t8PItKzriKTEJVIuq6oAApK8sizTIBHApKKQMqJABwSUVKQPCMqqoCYjIuKyUJTWXKT9Hvg--uL7ZQlcMXhqv0ztvh9EftjNWfN61d65V70CnNCJdsMBAHg9K7EDzU71pK9Asi_YJI7xFpxjTTA6JB9uNj7rvojQl_BqE7jiw</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Mahmood, Nosheen</creator><creator>Mushtaq, Shamim</creator><creator>Jamal, Qamar</creator><creator>Hanif, Muhammad</creator><creator>Akhlaq, Humera</creator><creator>Rehman, Dur-e-Shewar</creator><creator>Awan, Rashid</creator><general>West Asia Organization for Cancer Prevention</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6269-9457</orcidid></search><sort><creationdate>20210201</creationdate><title>Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma</title><author>Mahmood, Nosheen ; Mushtaq, Shamim ; Jamal, Qamar ; Hanif, Muhammad ; Akhlaq, Humera ; Rehman, Dur-e-Shewar ; Awan, Rashid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3237-a61764ffb1ee82ccb8994e3eb1112e145eee351480e43917dde0a935d75018583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahmood, Nosheen</creatorcontrib><creatorcontrib>Mushtaq, Shamim</creatorcontrib><creatorcontrib>Jamal, Qamar</creatorcontrib><creatorcontrib>Hanif, Muhammad</creatorcontrib><creatorcontrib>Akhlaq, Humera</creatorcontrib><creatorcontrib>Rehman, Dur-e-Shewar</creatorcontrib><creatorcontrib>Awan, Rashid</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahmood, Nosheen</au><au>Mushtaq, Shamim</au><au>Jamal, Qamar</au><au>Hanif, Muhammad</au><au>Akhlaq, Humera</au><au>Rehman, Dur-e-Shewar</au><au>Awan, Rashid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>22</volume><issue>2</issue><spage>407</spage><epage>412</epage><pages>407-412</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognostic relevance of HMGA2 in liquid biopsies of oral cancer patients. After obtaining approval from Institutional Review Board of Ziauddin University and informed written consent from study subjects, expression of circulating HMGA2 was evaluated in 96 OSCC cases and 100 age and sex matched controls via real time PCR using specific set of primers. We further analyzed relationship of various sociodemographic and clinicopathological variables with HMGA2expression and explored its prognostic potential. Expression was seen in 22 (23%) cases. A higher expression was observed among subjects with local invasion (52.6% vs 47.4 %), distant metastasis (71.4% vs 28.6%) and tumor recurrence (57.1% vs 42.9%) p.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>33639654</pmid><doi>10.31557/APJCP.2021.22.2.407</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6269-9457</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2476-762X
ispartof Asian Pacific Journal of Cancer Prevention, 2021-02, Vol.22 (2), p.407-412
issn 2476-762X
1513-7368
2476-762X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8190352
source Freely Accessible Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
title Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T17%3A46%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20Utility%20of%20Cell%20Free%20High%20Mobility%20Group%20AT-hook%202%20(HMGA2)%20as%20a%20Prognostic%20Biomarker%20in%20Liquid%20Biopsies%20of%20Oral%20Squamous%20Cell%20Carcinoma&rft.jtitle=Asian%20Pacific%20Journal%20of%20Cancer%20Prevention&rft.au=Mahmood,%20Nosheen&rft.date=2021-02-01&rft.volume=22&rft.issue=2&rft.spage=407&rft.epage=412&rft.pages=407-412&rft.issn=2476-762X&rft.eissn=2476-762X&rft_id=info:doi/10.31557/APJCP.2021.22.2.407&rft_dat=%3Cpubmed_cross%3E33639654%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/33639654&rfr_iscdi=true