Computational modeling of tau pathology spread reveals patterns of regional vulnerability and the impact of a genetic risk factor

Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer's disease (AD) and other tauopathies, but it is unclear how neuroanatomical connections, spatial proximity, and regional vulnerability contribute. In this study, we seed tau pathology in t...

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Veröffentlicht in:	Science advances 2021-06, Vol.7 (24)
Hauptverfasser:	Cornblath, Eli J, Li, Howard L, Changolkar, Lakshmi, Zhang, Bin, Brown, Hannah J, Gathagan, Ronald J, Olufemi, Modupe F, Trojanowski, John Q, Bassett, Danielle S, Lee, Virginia M Y, Henderson, Michael X
Format:	Artikel
Sprache:	eng
Schlagworte:	Network Science Neuroscience SciAdv r-articles
Online-Zugang:	Volltext
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