Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease
•Controls and PD groups and were compared on a qualitative measure of verbal fluency.•Right symptom-onset PD subjects produced words of an earlier age of acquisition (AoA).•AoA of responses showed a positive correlation with putamen volume in this group.•Controls showed a negative correlation with A...
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| Veröffentlicht in: | Brain and language 2020-10, Vol.209, p.104841-104841, Article 104841 |
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| creator | Wagner, Daymond Eslinger, Paul J. Sterling, Nicholas W. Du, Guangwei Lee, Eun-Young Styner, Martin Lewis, Mechelle M. Huang, Xuemei |
| description | •Controls and PD groups and were compared on a qualitative measure of verbal fluency.•Right symptom-onset PD subjects produced words of an earlier age of acquisition (AoA).•AoA of responses showed a positive correlation with putamen volume in this group.•Controls showed a negative correlation with AoA of responses and caudate volume.•Findings supported a role for the striatum in the access of the lexical-semantic system.
Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p |
| doi_str_mv | 10.1016/j.bandl.2020.104841 |
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Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.</description><identifier>ISSN: 0093-934X</identifier><identifier>ISSN: 1090-2155</identifier><identifier>EISSN: 1090-2155</identifier><identifier>DOI: 10.1016/j.bandl.2020.104841</identifier><identifier>PMID: 32818719</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Age ; Age Factors ; Age of acquisition ; Aged ; Basal ganglia ; Brain ; Case-Control Studies ; Cognition ; Corpus Striatum - pathology ; Female ; Fluency ; Functional Laterality - physiology ; Humans ; Language Development ; Language Disorders - etiology ; Language Disorders - pathology ; Language Disorders - physiopathology ; Lexical access ; Lexical semantics ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor asymmetry ; MRI ; Organ Size ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson Disease - psychology ; Parkinson's disease ; Patients ; Putamen - pathology ; Semantic processing ; Semantics ; Striatal volume ; Voxel-based morphometry ; Word frequency</subject><ispartof>Brain and language, 2020-10, Vol.209, p.104841-104841, Article 104841</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><rights>Copyright Academic Press Oct 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4021-bdc87a64c54c42c4644df488627a2f45635658403a671b75d3c5e18d9ae452e03</citedby><cites>FETCH-LOGICAL-c4021-bdc87a64c54c42c4644df488627a2f45635658403a671b75d3c5e18d9ae452e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bandl.2020.104841$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32818719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wagner, Daymond</creatorcontrib><creatorcontrib>Eslinger, Paul J.</creatorcontrib><creatorcontrib>Sterling, Nicholas W.</creatorcontrib><creatorcontrib>Du, Guangwei</creatorcontrib><creatorcontrib>Lee, Eun-Young</creatorcontrib><creatorcontrib>Styner, Martin</creatorcontrib><creatorcontrib>Lewis, Mechelle M.</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><title>Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease</title><title>Brain and language</title><addtitle>Brain Lang</addtitle><description>•Controls and PD groups and were compared on a qualitative measure of verbal fluency.•Right symptom-onset PD subjects produced words of an earlier age of acquisition (AoA).•AoA of responses showed a positive correlation with putamen volume in this group.•Controls showed a negative correlation with AoA of responses and caudate volume.•Findings supported a role for the striatum in the access of the lexical-semantic system.
Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.</description><subject>Age</subject><subject>Age Factors</subject><subject>Age of acquisition</subject><subject>Aged</subject><subject>Basal ganglia</subject><subject>Brain</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Corpus Striatum - pathology</subject><subject>Female</subject><subject>Fluency</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Language Development</subject><subject>Language Disorders - etiology</subject><subject>Language Disorders - pathology</subject><subject>Language Disorders - physiopathology</subject><subject>Lexical access</subject><subject>Lexical semantics</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor asymmetry</subject><subject>MRI</subject><subject>Organ Size</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - psychology</subject><subject>Parkinson's disease</subject><subject>Patients</subject><subject>Putamen - pathology</subject><subject>Semantic processing</subject><subject>Semantics</subject><subject>Striatal volume</subject><subject>Voxel-based morphometry</subject><subject>Word frequency</subject><issn>0093-934X</issn><issn>1090-2155</issn><issn>1090-2155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGKFDEQhoO4uLOrTyBIwIuXHpN0Jd19UFgWXYWB9aDgQQiZpNrN2J2MSfegN1_D19snMeOsi-vBU0Hqq79S_0_IY86WnHH1fLNcm-CGpWBi_wIt8HtkwVnHKsGlvE8WjHV11dXw8Zic5LxhjHNo-QNyXIuWtw3vFuTTCr95a4Yq42jC5C3NaJK9ogkHM6GjU6TZO6SxpzFknGjZSbfzZEYMdBeHeUTqA31n0hcfcgzXP35m6nxRyfiQHPVmyPjopp6SD69fvT9_U60uL96en60qC0zwau1s2xgFVoIFYUEBuB7aVonGiB6kqqWSLbDaqIavG-lqK5G3rjMIUiCrT8nLg-52Xo_oLIYpmUFvkx9N-q6j8fpuJ_gr_TnudHGhU0oVgWc3Ail-nTFPevTZ4jCYgHHOWkCtoHje7dGn_6CbOKdQzisUNB00UkKh6gNlU8w5YX_7Gc70Pj290b_T0_v09CG9MvXk7ztuZ_7EVYAXBwCLmzuPSWfrMVh0PqGdtIv-vwt-AfBtrOs</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Wagner, Daymond</creator><creator>Eslinger, Paul J.</creator><creator>Sterling, Nicholas W.</creator><creator>Du, Guangwei</creator><creator>Lee, Eun-Young</creator><creator>Styner, Martin</creator><creator>Lewis, Mechelle M.</creator><creator>Huang, Xuemei</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T9</scope><scope>8BM</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease</title><author>Wagner, Daymond ; Eslinger, Paul J. ; Sterling, Nicholas W. ; Du, Guangwei ; Lee, Eun-Young ; Styner, Martin ; Lewis, Mechelle M. ; Huang, Xuemei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4021-bdc87a64c54c42c4644df488627a2f45635658403a671b75d3c5e18d9ae452e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Age of acquisition</topic><topic>Aged</topic><topic>Basal ganglia</topic><topic>Brain</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Corpus Striatum - pathology</topic><topic>Female</topic><topic>Fluency</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Language Development</topic><topic>Language Disorders - etiology</topic><topic>Language Disorders - pathology</topic><topic>Language Disorders - physiopathology</topic><topic>Lexical access</topic><topic>Lexical semantics</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor asymmetry</topic><topic>MRI</topic><topic>Organ Size</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - psychology</topic><topic>Parkinson's disease</topic><topic>Patients</topic><topic>Putamen - pathology</topic><topic>Semantic processing</topic><topic>Semantics</topic><topic>Striatal volume</topic><topic>Voxel-based morphometry</topic><topic>Word frequency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagner, Daymond</creatorcontrib><creatorcontrib>Eslinger, Paul J.</creatorcontrib><creatorcontrib>Sterling, Nicholas W.</creatorcontrib><creatorcontrib>Du, Guangwei</creatorcontrib><creatorcontrib>Lee, Eun-Young</creatorcontrib><creatorcontrib>Styner, Martin</creatorcontrib><creatorcontrib>Lewis, Mechelle M.</creatorcontrib><creatorcontrib>Huang, Xuemei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Linguistics and Language Behavior Abstracts (LLBA)</collection><collection>ComDisDome</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain and language</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagner, Daymond</au><au>Eslinger, Paul J.</au><au>Sterling, Nicholas W.</au><au>Du, Guangwei</au><au>Lee, Eun-Young</au><au>Styner, Martin</au><au>Lewis, Mechelle M.</au><au>Huang, Xuemei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease</atitle><jtitle>Brain and language</jtitle><addtitle>Brain Lang</addtitle><date>2020-10-01</date><risdate>2020</risdate><volume>209</volume><spage>104841</spage><epage>104841</epage><pages>104841-104841</pages><artnum>104841</artnum><issn>0093-934X</issn><issn>1090-2155</issn><eissn>1090-2155</eissn><abstract>•Controls and PD groups and were compared on a qualitative measure of verbal fluency.•Right symptom-onset PD subjects produced words of an earlier age of acquisition (AoA).•AoA of responses showed a positive correlation with putamen volume in this group.•Controls showed a negative correlation with AoA of responses and caudate volume.•Findings supported a role for the striatum in the access of the lexical-semantic system.
Parkinson's disease (PD) is characterized by dopaminergic cell loss and reduced striatal volume. Prior studies have demonstrated striatal involvement in access to lexical-semantic knowledge and damage to this structure may be evident in the lexical properties of responses. Semantic fluency task responses from early stage, non-demented PD participants with right (PD-R) or left (PD-L) lateralizing symptoms were compared to matched controls on lexical properties (word frequency, age of acquisition) and correlated with striatal volumes segmented from T1-weighted brain MR images. PD-R participants produced semantic fluency responses of a lower age of acquisition than PD-L and control participants (p < 0.05). PD-R age of acquisition responses correlated positively with putamen volume (p < 0.05), while age of acquisition of responses correlated negatively with caudate volume in controls (p < 0.05). Findings provide evidence for a role of the striatum in lexical-semantic access and qualitative changes in lexical access in select PD patients.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>32818719</pmid><doi>10.1016/j.bandl.2020.104841</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Age Factors Age of acquisition Aged Basal ganglia Brain Case-Control Studies Cognition Corpus Striatum - pathology Female Fluency Functional Laterality - physiology Humans Language Development Language Disorders - etiology Language Disorders - pathology Language Disorders - physiopathology Lexical access Lexical semantics Magnetic Resonance Imaging Male Middle Aged Motor asymmetry MRI Organ Size Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson Disease - psychology Parkinson's disease Patients Putamen - pathology Semantic processing Semantics Striatal volume Voxel-based morphometry Word frequency |
| title | Lexical-semantic search related to side of onset and putamen volume in Parkinson’s disease |
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