Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

COVID-19 can cause severe neurological symptoms, but the underlying pathophysiological mechanisms are unclear. Here, we interrogated the brain stems and olfactory bulbs in postmortem patients who had COVID-19 using imaging mass cytometry to understand the local immune response at a spatially resolve...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-07, Vol.54 (7), p.1594-1610.e11
Hauptverfasser:	Schwabenland, Marius, Salié, Henrike, Tanevski, Jovan, Killmer, Saskia, Lago, Marilyn Salvat, Schlaak, Alexandra Emilia, Mayer, Lena, Matschke, Jakob, Püschel, Klaus, Fitzek, Antonia, Ondruschka, Benjamin, Mei, Henrik E., Boettler, Tobias, Neumann-Haefelin, Christoph, Hofmann, Maike, Breithaupt, Angele, Genc, Nafiye, Stadelmann, Christine, Saez-Rodriguez, Julio, Bronsert, Peter, Knobeloch, Klaus-Peter, Blank, Thomas, Thimme, Robert, Glatzel, Markus, Prinz, Marco, Bengsch, Bertram
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Brain brain autopsy Brain damage Brain injury CD8 antigen Cell interactions Central nervous system Coronaviruses COVID-19 Cytometry Cytotoxicity Depth profiling encephalopathy Extracorporeal membrane oxygenation Gliosis Hemostasis Hemostatics high-dimensional imaging Immune response Immune system Infections Inflammation Lymphocytes Lymphocytes T mass cytometry Microglia Morphology Multiple sclerosis Neuroimaging neuroinflammation Neuropathology Nodules Olfactory bulb Pathology Patients Respiratory failure SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 single-cell analysis T cells
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